Antimicrobial effects of black rice extract on Helicobacter pylori infection in Mongolian gerbil

Sa Hyun Kim, Hyun Jun Woo, Min Ho Lee, Min Park, Tharmalingam Nagendran, Ki Jong Rhee, Dongsup Lee, Yeung Bae Jin, Sik Won Choi, Woo Duck Seo, Jong Bae Kim

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


It has been reported that cyanidin 3-O-glucoside (C3G) is an inhibitor of Helicobacter pylori toxin secretion. C3G is classified as an anthocyanin and is a major component of black rice extract (BRE). The present study aimed to identify a new functional food material to prevent H. pylori infection in Mongolian gerbil model. Toxicity in the liver and kidney were not detected after BRE administration (10 or 50 mg/kg). BRE treatment reduced bacterial colonization in animal gastric tissue, as well as infection signs as observed on the analysis of the hematological data. It was also found that the relative mRNA levels of the inflammatory cytokines were reduced in BRE-treated groups. These findings suggest that BRE acts as a potent inhibitor of H. pylori infection and pathogenesis in Mongolian gerbils. We propose that BRE may be used to manage gastroduodenal diseases caused by H. pylori infection.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJournal of Cereal Science
Publication statusPublished - 2019 Jan 1

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Food Science
  • Biochemistry


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