Antibacterial poly (3,4-ethylenedioxythiophene):poly(styrene-sulfonate)/agarose nanocomposite hydrogels with thermo-processability and self-healing

Youngsang Ko; Jeonghun Kim; Ho Young Jeong; Goomin Kwon; Dabum Kim; Minhee Ku; Jaemoon Yang; Yusuke Yamauchi; Hae Yeong Kim; Chanhui Lee; Jungmok You

doi:10.1016/j.carbpol.2018.09.026

Antibacterial poly (3,4-ethylenedioxythiophene):poly(styrene-sulfonate)/agarose nanocomposite hydrogels with thermo-processability and self-healing

Youngsang Ko, Jeonghun Kim, Ho Young Jeong, Goomin Kwon, Dabum Kim, Minhee Ku, Jaemoon Yang, Yusuke Yamauchi, Hae Yeong Kim, Chanhui Lee, Jungmok You

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Recently, Near-infrared (NIR)-induced photothermal killing of pathogenic bacteria has received considerable attention due to the increase in antibiotic resistant bacteria. In this paper, we report a simple aqueous solution-based strategy to construct an effective photothermal nanocomposite composed of poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) and agarose with thermo-processability, light triggered self-healing, and excellent antibacterial activity. Our experiments revealed that PEDOT:PSS/agarose was easily coated on both a 2D glass substrate and 3D cotton structure. Additionally, PEDOT:PSS/agarose can be designed into free-standing objects of diverse shape as well as restored through an NIR light-induced self-healing effect after damage. Taking advantage of strong NIR light absorption, PEDOT:PSS/agarose exhibited a sharp temperature increase of 24.5 °C during NIR exposure for 100 s. More importantly, we demonstrated that the temperature increase on PEDOT:PSS/agarose via photothermal conversion resulted in the rapid and effective killing of nearly 100% of the pathogenic bacteria within 2 min of NIR irradiation.

Original language	English
Pages (from-to)	26-34
Number of pages	9
Journal	Carbohydrate Polymers
Volume	203
DOIs	https://doi.org/10.1016/j.carbpol.2018.09.026
Publication status	Published - 2019 Jan 1

Bibliographical note

Funding Information:
This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2017R1C1B2010867, 2018R1D1A1B07047874), a grant from Kyung Hee University in 2015 (KHU- 20152129), and a Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01279701) Rural Development Administration, Republic of Korea.

Publisher Copyright:
© 2018 Elsevier Ltd

All Science Journal Classification (ASJC) codes

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2018.09.026

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title = "Antibacterial poly (3,4-ethylenedioxythiophene):poly(styrene-sulfonate)/agarose nanocomposite hydrogels with thermo-processability and self-healing",

abstract = "Recently, Near-infrared (NIR)-induced photothermal killing of pathogenic bacteria has received considerable attention due to the increase in antibiotic resistant bacteria. In this paper, we report a simple aqueous solution-based strategy to construct an effective photothermal nanocomposite composed of poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) and agarose with thermo-processability, light triggered self-healing, and excellent antibacterial activity. Our experiments revealed that PEDOT:PSS/agarose was easily coated on both a 2D glass substrate and 3D cotton structure. Additionally, PEDOT:PSS/agarose can be designed into free-standing objects of diverse shape as well as restored through an NIR light-induced self-healing effect after damage. Taking advantage of strong NIR light absorption, PEDOT:PSS/agarose exhibited a sharp temperature increase of 24.5 °C during NIR exposure for 100 s. More importantly, we demonstrated that the temperature increase on PEDOT:PSS/agarose via photothermal conversion resulted in the rapid and effective killing of nearly 100% of the pathogenic bacteria within 2 min of NIR irradiation.",

author = "Youngsang Ko and Jeonghun Kim and Jeong, {Ho Young} and Goomin Kwon and Dabum Kim and Minhee Ku and Jaemoon Yang and Yusuke Yamauchi and Kim, {Hae Yeong} and Chanhui Lee and Jungmok You",

note = "Funding Information: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2017R1C1B2010867, 2018R1D1A1B07047874), a grant from Kyung Hee University in 2015 (KHU- 20152129), and a Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01279701) Rural Development Administration, Republic of Korea. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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doi = "10.1016/j.carbpol.2018.09.026",

language = "English",

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T1 - Antibacterial poly (3,4-ethylenedioxythiophene):poly(styrene-sulfonate)/agarose nanocomposite hydrogels with thermo-processability and self-healing

AU - Ko, Youngsang

AU - Kim, Jeonghun

AU - Jeong, Ho Young

AU - Kwon, Goomin

AU - Kim, Dabum

AU - Ku, Minhee

AU - Yang, Jaemoon

AU - Yamauchi, Yusuke

AU - Kim, Hae Yeong

AU - Lee, Chanhui

AU - You, Jungmok

N1 - Funding Information: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2017R1C1B2010867, 2018R1D1A1B07047874), a grant from Kyung Hee University in 2015 (KHU- 20152129), and a Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01279701) Rural Development Administration, Republic of Korea. Publisher Copyright: © 2018 Elsevier Ltd

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Recently, Near-infrared (NIR)-induced photothermal killing of pathogenic bacteria has received considerable attention due to the increase in antibiotic resistant bacteria. In this paper, we report a simple aqueous solution-based strategy to construct an effective photothermal nanocomposite composed of poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) and agarose with thermo-processability, light triggered self-healing, and excellent antibacterial activity. Our experiments revealed that PEDOT:PSS/agarose was easily coated on both a 2D glass substrate and 3D cotton structure. Additionally, PEDOT:PSS/agarose can be designed into free-standing objects of diverse shape as well as restored through an NIR light-induced self-healing effect after damage. Taking advantage of strong NIR light absorption, PEDOT:PSS/agarose exhibited a sharp temperature increase of 24.5 °C during NIR exposure for 100 s. More importantly, we demonstrated that the temperature increase on PEDOT:PSS/agarose via photothermal conversion resulted in the rapid and effective killing of nearly 100% of the pathogenic bacteria within 2 min of NIR irradiation.

AB - Recently, Near-infrared (NIR)-induced photothermal killing of pathogenic bacteria has received considerable attention due to the increase in antibiotic resistant bacteria. In this paper, we report a simple aqueous solution-based strategy to construct an effective photothermal nanocomposite composed of poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) and agarose with thermo-processability, light triggered self-healing, and excellent antibacterial activity. Our experiments revealed that PEDOT:PSS/agarose was easily coated on both a 2D glass substrate and 3D cotton structure. Additionally, PEDOT:PSS/agarose can be designed into free-standing objects of diverse shape as well as restored through an NIR light-induced self-healing effect after damage. Taking advantage of strong NIR light absorption, PEDOT:PSS/agarose exhibited a sharp temperature increase of 24.5 °C during NIR exposure for 100 s. More importantly, we demonstrated that the temperature increase on PEDOT:PSS/agarose via photothermal conversion resulted in the rapid and effective killing of nearly 100% of the pathogenic bacteria within 2 min of NIR irradiation.

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Antibacterial poly (3,4-ethylenedioxythiophene):poly(styrene-sulfonate)/agarose nanocomposite hydrogels with thermo-processability and self-healing

Abstract

Bibliographical note

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