A naringin-containing soft contact lens (NCSC) was prepared as an antibacterial platform for long-term wearable soft contact lens. The NCSC showed sustained release of naringin for about a period of 1 month without changing the surface morphology. The effluent solution from NCSC exhibited very low cytotoxicity and high antibacterial activities against Pseudomonas aeruginosa and Escherichia coli. In the intraocular eye drop experiments of effluent solution from NCSC, it had no difference with the control group and showed unstimulated status without any cell damage or side effect. The NCSC showed smoother surface with reduced contamination by P. aeruginosa after wearing of 3 consecutive weeks whereas the control soft contact lens showed extremely high contamination, indicating the effective antibacterial effect of NCSC upon extended wearing.
Bibliographical notePublisher Copyright:
© 2021 Korean Chemical Society and Wiley-VCH GmbH.
All Science Journal Classification (ASJC) codes
- General Chemistry