Anti-tuberculosis effects of frankincense through immune responses of Mycobacterium tuberculosis-infected macrophages

Eun Soon Son, Sun Kyoung Lee, Sang Nae Cho, Hae Ryoung Park, Jong Seok Lee

Research output: Contribution to journalArticlepeer-review


Frankincense has been used as a traditional medicine for treating rheumatoid arthritis, dermatitis, and muscle pain. In this study, the anti-tuberculosis effects of Frankincense were evaluated in immune responses of macrophages. Frankincense methanol extract was not cytotoxic to the host. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay using human macrophage (THP-1) cells did not show cytotoxic effects or morphological changes with treatments of 31.3, 62.5, and 125 μg/mL Frankincense methanol extract (FRM). Inhibitory effects of Frankincense methanol extract on the growth of Mycobacterium tuberculosis in human macrophages were investigated. The immune response was measured by monitoring the levels of TNF-α and IL-1β in THP-1 cells with or without M. tuberculosis infection under Frankincense methanol extract treatment. Inflammatory cytokine levels and M. tuberculosis numbers were reduced in THP-1 cells treated with Frankincense methanol extract. Therefore, Frankincense methanol extract could be used as a potential anti-tuberculosis agent.

Original languageEnglish
Pages (from-to)756-760
Number of pages5
JournalKorean Journal of Food Science and Technology
Issue number6
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 Korean Society of Food Science and Technology. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


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