Anti-promotion effect of chlorophyllin in DMBA-TPA-Induced mouse skin carcinogenesis

Jin Kim; Jong In Yook; Kwang Kyun Park; So Young Jung; Joon Chul Hong; Kyung Ju Kim; Jin A. Kim; Won Yoon Chung

Anti-promotion effect of chlorophyllin in DMBA-TPA-Induced mouse skin carcinogenesis

Jin Kim, Jong In Yook, Kwang Kyun Park, So Young Jung, Joon Chul Hong, Kyung Ju Kim, Jin A. Kim, Won Yoon Chung

Research output: Contribution to journal › Article › peer-review

Abstract

This study aimed to elucidate the inhibitory effects of Chlorophyllin (CHL) at different promotion stages in a DMBA-TPA-induced mouse skin carcinogenesis model. TPA promotion was undertaken for 6, 18 and 24 weeks, respectively. Proliferating activity was observed immunohistochemically and the ornithine decarboxylase (ODC) mRNA level was analyzed by reverse transcriptase-polymerase chain reaction. Messenger RNAs for c-fos, c-jun and jun-B were also observed CHL treatment clearly reduced proliferating activity and the level of ODC mRNA at the 18-week-promotion stage. When promoted for 24 weeks, CHL was not effective in reducing proliferating activity and ODC mRNA expression. These results indicate that the promotion stage of each target tissue should be considered in a chemopreventive program.

Original language	English
Pages (from-to)	1493-1498
Number of pages	6
Journal	Anticancer research
Volume	20
Issue number	3 A
Publication status	Published - 2000

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Anti-promotion effect of chlorophyllin in DMBA-TPA-Induced mouse skin carcinogenesis",

abstract = "This study aimed to elucidate the inhibitory effects of Chlorophyllin (CHL) at different promotion stages in a DMBA-TPA-induced mouse skin carcinogenesis model. TPA promotion was undertaken for 6, 18 and 24 weeks, respectively. Proliferating activity was observed immunohistochemically and the ornithine decarboxylase (ODC) mRNA level was analyzed by reverse transcriptase-polymerase chain reaction. Messenger RNAs for c-fos, c-jun and jun-B were also observed CHL treatment clearly reduced proliferating activity and the level of ODC mRNA at the 18-week-promotion stage. When promoted for 24 weeks, CHL was not effective in reducing proliferating activity and ODC mRNA expression. These results indicate that the promotion stage of each target tissue should be considered in a chemopreventive program.",

author = "Jin Kim and Yook, {Jong In} and Park, {Kwang Kyun} and Jung, {So Young} and Hong, {Joon Chul} and Kim, {Kyung Ju} and Kim, {Jin A.} and Chung, {Won Yoon}",

year = "2000",

language = "English",

volume = "20",

pages = "1493--1498",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Anti-promotion effect of chlorophyllin in DMBA-TPA-Induced mouse skin carcinogenesis

AU - Kim, Jin

AU - Yook, Jong In

AU - Park, Kwang Kyun

AU - Jung, So Young

AU - Hong, Joon Chul

AU - Kim, Kyung Ju

AU - Kim, Jin A.

AU - Chung, Won Yoon

PY - 2000

Y1 - 2000

N2 - This study aimed to elucidate the inhibitory effects of Chlorophyllin (CHL) at different promotion stages in a DMBA-TPA-induced mouse skin carcinogenesis model. TPA promotion was undertaken for 6, 18 and 24 weeks, respectively. Proliferating activity was observed immunohistochemically and the ornithine decarboxylase (ODC) mRNA level was analyzed by reverse transcriptase-polymerase chain reaction. Messenger RNAs for c-fos, c-jun and jun-B were also observed CHL treatment clearly reduced proliferating activity and the level of ODC mRNA at the 18-week-promotion stage. When promoted for 24 weeks, CHL was not effective in reducing proliferating activity and ODC mRNA expression. These results indicate that the promotion stage of each target tissue should be considered in a chemopreventive program.

AB - This study aimed to elucidate the inhibitory effects of Chlorophyllin (CHL) at different promotion stages in a DMBA-TPA-induced mouse skin carcinogenesis model. TPA promotion was undertaken for 6, 18 and 24 weeks, respectively. Proliferating activity was observed immunohistochemically and the ornithine decarboxylase (ODC) mRNA level was analyzed by reverse transcriptase-polymerase chain reaction. Messenger RNAs for c-fos, c-jun and jun-B were also observed CHL treatment clearly reduced proliferating activity and the level of ODC mRNA at the 18-week-promotion stage. When promoted for 24 weeks, CHL was not effective in reducing proliferating activity and ODC mRNA expression. These results indicate that the promotion stage of each target tissue should be considered in a chemopreventive program.

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M3 - Article

C2 - 10928061

AN - SCOPUS:0033854437

SN - 0250-7005

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JO - Anticancer research

JF - Anticancer research

IS - 3 A

ER -

Anti-promotion effect of chlorophyllin in DMBA-TPA-Induced mouse skin carcinogenesis

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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