Anti-promotion effect of chlorophyllin in DMBA-TPA-Induced mouse skin carcinogenesis

Jin Kim, Jong In Yook, Kwang Kyun Park, So Young Jung, Joon Chul Hong, Kyung Ju Kim, Jin A. Kim, Won Yoon Chung

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


This study aimed to elucidate the inhibitory effects of Chlorophyllin (CHL) at different promotion stages in a DMBA-TPA-induced mouse skin carcinogenesis model. TPA promotion was undertaken for 6, 18 and 24 weeks, respectively. Proliferating activity was observed immunohistochemically and the ornithine decarboxylase (ODC) mRNA level was analyzed by reverse transcriptase-polymerase chain reaction. Messenger RNAs for c-fos, c-jun and jun-B were also observed CHL treatment clearly reduced proliferating activity and the level of ODC mRNA at the 18-week-promotion stage. When promoted for 24 weeks, CHL was not effective in reducing proliferating activity and ODC mRNA expression. These results indicate that the promotion stage of each target tissue should be considered in a chemopreventive program.

Original languageEnglish
Pages (from-to)1493-1498
Number of pages6
JournalAnticancer research
Issue number3 A
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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