Anti-photoaging effects of 2-methoxy-5-(2-methyl propyl) pyrazine isolated from peach (Prunus persica (L.) Batsch)

Sunghwa Han; Jae Kwan Hwang; Kwang Kyun Park; Won Yoon Chung; Sang Kook Lee; Jaekyung Kim

doi:10.1007/s10068-010-0236-2

Anti-photoaging effects of 2-methoxy-5-(2-methyl propyl) pyrazine isolated from peach (Prunus persica (L.) Batsch)

Sunghwa Han, Jae Kwan Hwang, Kwang Kyun Park, Won Yoon Chung, Sang Kook Lee, Jaekyung Kim

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibroblasts. MMPP was obtained from the butanol fraction of a 95% ethanol extract of peach. The antioxidant and anti-photoaging activity of MMPP were assessed by 1,1-diphenyl-2-picrylhydrazy (DPPH), Western blot, and reverse trans-cription-polymerase chain reaction (RT-PCR) analyses. MMPP displayed radical scavenging activity, suppressed MMP-1 expression, and increased type-1 procollagen expression. These results support the use of MMPP from peach as an antiphotoaging compound.

Original language	English
Pages (from-to)	1667-1671
Number of pages	5
Journal	Food Science and Biotechnology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1007/s10068-010-0236-2
Publication status	Published - 2010

Bibliographical note

Funding Information:
Acknowledgments This work was supported by a grant from the BioGreen 21 Program, Rural Development Administration, Republic of Korea, and the Yonsei Biomolecule Research Intiative of the Brain Korea 21 Project.

All Science Journal Classification (ASJC) codes

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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title = "Anti-photoaging effects of 2-methoxy-5-(2-methyl propyl) pyrazine isolated from peach (Prunus persica (L.) Batsch)",

abstract = "In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibroblasts. MMPP was obtained from the butanol fraction of a 95% ethanol extract of peach. The antioxidant and anti-photoaging activity of MMPP were assessed by 1,1-diphenyl-2-picrylhydrazy (DPPH), Western blot, and reverse trans-cription-polymerase chain reaction (RT-PCR) analyses. MMPP displayed radical scavenging activity, suppressed MMP-1 expression, and increased type-1 procollagen expression. These results support the use of MMPP from peach as an antiphotoaging compound.",

author = "Sunghwa Han and Hwang, {Jae Kwan} and Park, {Kwang Kyun} and Chung, {Won Yoon} and Lee, {Sang Kook} and Jaekyung Kim",

note = "Funding Information: Acknowledgments This work was supported by a grant from the BioGreen 21 Program, Rural Development Administration, Republic of Korea, and the Yonsei Biomolecule Research Intiative of the Brain Korea 21 Project.",

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doi = "10.1007/s10068-010-0236-2",

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AU - Han, Sunghwa

AU - Hwang, Jae Kwan

AU - Park, Kwang Kyun

AU - Chung, Won Yoon

AU - Lee, Sang Kook

AU - Kim, Jaekyung

N1 - Funding Information: Acknowledgments This work was supported by a grant from the BioGreen 21 Program, Rural Development Administration, Republic of Korea, and the Yonsei Biomolecule Research Intiative of the Brain Korea 21 Project.

PY - 2010

Y1 - 2010

N2 - In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibroblasts. MMPP was obtained from the butanol fraction of a 95% ethanol extract of peach. The antioxidant and anti-photoaging activity of MMPP were assessed by 1,1-diphenyl-2-picrylhydrazy (DPPH), Western blot, and reverse trans-cription-polymerase chain reaction (RT-PCR) analyses. MMPP displayed radical scavenging activity, suppressed MMP-1 expression, and increased type-1 procollagen expression. These results support the use of MMPP from peach as an antiphotoaging compound.

AB - In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibroblasts. MMPP was obtained from the butanol fraction of a 95% ethanol extract of peach. The antioxidant and anti-photoaging activity of MMPP were assessed by 1,1-diphenyl-2-picrylhydrazy (DPPH), Western blot, and reverse trans-cription-polymerase chain reaction (RT-PCR) analyses. MMPP displayed radical scavenging activity, suppressed MMP-1 expression, and increased type-1 procollagen expression. These results support the use of MMPP from peach as an antiphotoaging compound.

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Anti-photoaging effects of 2-methoxy-5-(2-methyl propyl) pyrazine isolated from peach (Prunus persica (L.) Batsch)

Abstract

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