Anti-photoaging effect of Korean mint (Agastache rugosa Kuntze) extract on UVB-irradiated human dermal fibroblasts

Heewon Seo, Changhee Kim, Mi Bo Kim, Jae Kwan Hwang

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) and stimulates the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. The current study aimed to assess the anti-photoaging activity of Agastache rugosa extract (ARE) on UVB-treated human dermal fibroblasts. ARE treatment reduced the overproduction of ROS and promoted mRNA expression of anti-oxidant enzymes. ARE treatment significantly inactivated the MAPK/AP-1 signaling pathway, which downregulated the expression of MMPs. Moreover, ARE promoted the production of type-I procollagen and upregulated mRNA expression of collagen genes. Additionally, ARE suppressed the expression of inflammatory cytokines, including interleukin (IL)-1β, IL-6, and IL-8, by preventing expression of nuclear factor-kappa B. Collectively, our findings show that ARE could be a potential candidate for anti-photoaging treatment.

Original languageEnglish
Pages (from-to)442-448
Number of pages7
JournalPreventive Nutrition and Food Science
Issue number4
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This work was supported by the World Class 300 Project R&D Program (S2435140) funded by the Small and Medium Business Administration (SMBA, Republic of

Publisher Copyright:
© 2019 by The Korean Society of Food Science and Nutrition. All rights Reserved.

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics


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