Abstract
Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) and stimulates the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. The current study aimed to assess the anti-photoaging activity of Agastache rugosa extract (ARE) on UVB-treated human dermal fibroblasts. ARE treatment reduced the overproduction of ROS and promoted mRNA expression of anti-oxidant enzymes. ARE treatment significantly inactivated the MAPK/AP-1 signaling pathway, which downregulated the expression of MMPs. Moreover, ARE promoted the production of type-I procollagen and upregulated mRNA expression of collagen genes. Additionally, ARE suppressed the expression of inflammatory cytokines, including interleukin (IL)-1β, IL-6, and IL-8, by preventing expression of nuclear factor-kappa B. Collectively, our findings show that ARE could be a potential candidate for anti-photoaging treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 442-448 |
| Number of pages | 7 |
| Journal | Preventive Nutrition and Food Science |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2019 |
Bibliographical note
Funding Information:This work was supported by the World Class 300 Project R&D Program (S2435140) funded by the Small and Medium Business Administration (SMBA, Republic of
Publisher Copyright:
© 2019 by The Korean Society of Food Science and Nutrition. All rights Reserved.
All Science Journal Classification (ASJC) codes
- Food Science
- Nutrition and Dietetics