Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat

So Hyung Hong; Ki Tae Suk; Sang Hyeon Choi; Jung Wook Lee; Ho Taik Sung; Chang Hoon Kim; Eun Ji Kim; Myoung Jo Kim; Sang Hak Han; Moon Young Kim; Soon Koo Baik; Dong Joon Kim; Gyoung Ja Lee; Sang kyu Lee; Seung Ha Park; Ohk Hyun Ryu

doi:10.1016/j.fct.2013.01.022

Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat

So Hyung Hong, Ki Tae Suk, Sang Hyeon Choi, Jung Wook Lee, Ho Taik Sung, Chang Hoon Kim, Eun Ji Kim, Myoung Jo Kim, Sang Hak Han, Moon Young Kim, Soon Koo Baik, Dong Joon Kim, Gyoung Ja Lee, Sang kyu Lee, Seung Ha Park, Ohk Hyun Ryu

Internal Medicine

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10. months; after this period. The OLETF rats were divided into the following four groups according to diet for 2. months: NAFLD (chew), KRG (chew. +. KRG [200. mg/kg/day]), urushiol (chew. +. urushiol [0.5. mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew. +. UDCA [15. mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0. ±. 70.4 and 275.2. ±. 63.8] vs. 527.7. ±. 153.3. mg/dL) were lower compared with that of NAFLD group (p<. 0.05). The levels of HDL-cholesterol (liver tissue: [4.8. ±. 0.2 and 4.8. ±. 0.5] vs. 4.2. ±. 0.2. mg/g) and NK cell activity ([3485. ±. 910 and 3559. ±. 910] vs. 2486. ±. 619 counts) were significantly higher than those of the NAFLD group (p<. 0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2. months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats.

Original language	English
Pages (from-to)	586-591
Number of pages	6
Journal	Food and Chemical Toxicology
Volume	55
DOIs	https://doi.org/10.1016/j.fct.2013.01.022
Publication status	Published - 2013 May

Bibliographical note

Funding Information:
This research was partly supported by a grant from the Korea Society of Ginseng funded by Korea Ginseng Corporation, by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012–0007552) by a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea. (A102065), and by the Medical Center Research funded by the Hallym University (01-2010-01).

Funding Information:
Rats were supported by the Ostsuka company (Ostuka, Inc., Tokushima, Japan).

All Science Journal Classification (ASJC) codes

Food Science
Toxicology

Access to Document

10.1016/j.fct.2013.01.022

Cite this

Hong, S. H., Suk, K. T., Choi, S. H., Lee, J. W., Sung, H. T., Kim, C. H., Kim, E. J., Kim, M. J., Han, S. H., Kim, M. Y., Baik, S. K., Kim, D. J., Lee, G. J., Lee, S. K., Park, S. H., & Ryu, O. H. (2013). Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat. Food and Chemical Toxicology, 55, 586-591. https://doi.org/10.1016/j.fct.2013.01.022

@article{d8c228032c6a4e34b2396f18617f92ce,

title = "Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat",

abstract = "Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10. months; after this period. The OLETF rats were divided into the following four groups according to diet for 2. months: NAFLD (chew), KRG (chew. +. KRG [200. mg/kg/day]), urushiol (chew. +. urushiol [0.5. mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew. +. UDCA [15. mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0. ±. 70.4 and 275.2. ±. 63.8] vs. 527.7. ±. 153.3. mg/dL) were lower compared with that of NAFLD group (p<. 0.05). The levels of HDL-cholesterol (liver tissue: [4.8. ±. 0.2 and 4.8. ±. 0.5] vs. 4.2. ±. 0.2. mg/g) and NK cell activity ([3485. ±. 910 and 3559. ±. 910] vs. 2486. ±. 619 counts) were significantly higher than those of the NAFLD group (p<. 0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2. months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats.",

author = "Hong, {So Hyung} and Suk, {Ki Tae} and Choi, {Sang Hyeon} and Lee, {Jung Wook} and Sung, {Ho Taik} and Kim, {Chang Hoon} and Kim, {Eun Ji} and Kim, {Myoung Jo} and Han, {Sang Hak} and Kim, {Moon Young} and Baik, {Soon Koo} and Kim, {Dong Joon} and Lee, {Gyoung Ja} and Lee, {Sang kyu} and Park, {Seung Ha} and Ryu, {Ohk Hyun}",

note = "Funding Information: This research was partly supported by a grant from the Korea Society of Ginseng funded by Korea Ginseng Corporation, by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012–0007552) by a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea. (A102065), and by the Medical Center Research funded by the Hallym University (01-2010-01). Funding Information: Rats were supported by the Ostsuka company (Ostuka, Inc., Tokushima, Japan).",

year = "2013",

month = may,

doi = "10.1016/j.fct.2013.01.022",

language = "English",

volume = "55",

pages = "586--591",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Limited",

}

Hong, SH, Suk, KT, Choi, SH, Lee, JW, Sung, HT, Kim, CH, Kim, EJ, Kim, MJ, Han, SH, Kim, MY , Baik, SK, Kim, DJ, Lee, GJ, Lee, SK, Park, SH & Ryu, OH 2013, 'Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat', Food and Chemical Toxicology, vol. 55, pp. 586-591. https://doi.org/10.1016/j.fct.2013.01.022

TY - JOUR

T1 - Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat

AU - Hong, So Hyung

AU - Suk, Ki Tae

AU - Choi, Sang Hyeon

AU - Lee, Jung Wook

AU - Sung, Ho Taik

AU - Kim, Chang Hoon

AU - Kim, Eun Ji

AU - Kim, Myoung Jo

AU - Han, Sang Hak

AU - Kim, Moon Young

AU - Baik, Soon Koo

AU - Kim, Dong Joon

AU - Lee, Gyoung Ja

AU - Lee, Sang kyu

AU - Park, Seung Ha

AU - Ryu, Ohk Hyun

N1 - Funding Information: This research was partly supported by a grant from the Korea Society of Ginseng funded by Korea Ginseng Corporation, by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012–0007552) by a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea. (A102065), and by the Medical Center Research funded by the Hallym University (01-2010-01). Funding Information: Rats were supported by the Ostsuka company (Ostuka, Inc., Tokushima, Japan).

PY - 2013/5

Y1 - 2013/5

N2 - Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10. months; after this period. The OLETF rats were divided into the following four groups according to diet for 2. months: NAFLD (chew), KRG (chew. +. KRG [200. mg/kg/day]), urushiol (chew. +. urushiol [0.5. mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew. +. UDCA [15. mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0. ±. 70.4 and 275.2. ±. 63.8] vs. 527.7. ±. 153.3. mg/dL) were lower compared with that of NAFLD group (p<. 0.05). The levels of HDL-cholesterol (liver tissue: [4.8. ±. 0.2 and 4.8. ±. 0.5] vs. 4.2. ±. 0.2. mg/g) and NK cell activity ([3485. ±. 910 and 3559. ±. 910] vs. 2486. ±. 619 counts) were significantly higher than those of the NAFLD group (p<. 0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2. months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats.

AB - Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10. months; after this period. The OLETF rats were divided into the following four groups according to diet for 2. months: NAFLD (chew), KRG (chew. +. KRG [200. mg/kg/day]), urushiol (chew. +. urushiol [0.5. mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew. +. UDCA [15. mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0. ±. 70.4 and 275.2. ±. 63.8] vs. 527.7. ±. 153.3. mg/dL) were lower compared with that of NAFLD group (p<. 0.05). The levels of HDL-cholesterol (liver tissue: [4.8. ±. 0.2 and 4.8. ±. 0.5] vs. 4.2. ±. 0.2. mg/g) and NK cell activity ([3485. ±. 910 and 3559. ±. 910] vs. 2486. ±. 619 counts) were significantly higher than those of the NAFLD group (p<. 0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2. months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats.

UR - http://www.scopus.com/inward/record.url?scp=84874706082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874706082&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2013.01.022

DO - 10.1016/j.fct.2013.01.022

M3 - Article

C2 - 23369934

AN - SCOPUS:84874706082

SN - 0278-6915

VL - 55

SP - 586

EP - 591

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this