Anti-mycobacterial effects of the extract of humulus japonicus

Min Sun Hong, Eun Soon Son, Sung Joong Lee, Sun Kyoung Lee, Ye Jin Lee, Sun Dae Song, Sang Nae Cho, Clifton E. Barry, Seok Yong Eum

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The present study aimed to evaluate the in vitro antimycobacterial effects of hop plant, Humulus japonicus. Methanol extract of H. japonicus (MeOH extract) showed strong direct bactericidal effects against Mycobacterium tuberculosis in vitro. Furthermore, the MeOH extract significantly inhibited M. tuberculosis growth in human macrophages. When five fractions obtained from MeOH extract were examined using the same methods, the hexane and ethyl acetate fractions showed bactericidal effects against M. tuberculosis in vitro, whereas the butanol and water fractions inhibited M. tuberculosis growth in macrophages. Because H. japonicus extract exhibited antimycobacterial activity against both free M. tuberculosis in culture medium and intracellular M. tuberculosis in human macrophages, this plant might be a good candidate for development of a new anti-tuberculosis drug.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalKorean Journal of Food Science and Technology
Issue number1
Publication statusPublished - 2014 Feb 28

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


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