Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata

Joong Sup Shim; Jin Hee Kim; Jiyong Lee; Si Na Kim; Ho Jeong Kwon

doi:10.1055/s-2004-815496

Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata

Joong Sup Shim, Jin Hee Kim, Jiyong Lee, Si Na Kim, Ho Jeong Kwon

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6- methoxychroman-4-one (1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

Original language	English
Pages (from-to)	171-173
Number of pages	3
Journal	Planta Medica
Volume	70
Issue number	2
DOIs	https://doi.org/10.1055/s-2004-815496
Publication status	Published - 2004 Feb

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata",

abstract = "A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6- methoxychroman-4-one (1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.",

author = "Shim, {Joong Sup} and Kim, {Jin Hee} and Jiyong Lee and Kim, {Si Na} and Kwon, {Ho Jeong}",

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language = "English",

volume = "70",

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AU - Shim, Joong Sup

AU - Kim, Jin Hee

AU - Lee, Jiyong

AU - Kim, Si Na

AU - Kwon, Ho Jeong

PY - 2004/2

Y1 - 2004/2

N2 - A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6- methoxychroman-4-one (1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

AB - A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6- methoxychroman-4-one (1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

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JO - Planta Medica

JF - Planta Medica

IS - 2

ER -

Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata

Abstract

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