Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata

Joong Sup Shim, Jin Hee Kim, Jiyong Lee, Si Na Kim, Ho Jeong Kwon

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)


A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6- methoxychroman-4-one (1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

Original languageEnglish
Pages (from-to)171-173
Number of pages3
JournalPlanta Medica
Issue number2
Publication statusPublished - 2004 Feb

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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