Anti- and pro-fibrillatory effects of pulmonary vein isolation gaps in human atrial fibrillation digital twins

Ze Jin, Taehyun Hwang, Daehoon Kim, Byounghyun Lim, Oh Seok Kwon, Sangbin Kim, Moon Hyun Kim, Je Wook Park, Hee Tae Yu, Tae Hoon Kim, Jae Sun Uhm, Boyoung Joung, Moon Hyoung Lee, Hui Nam Pak

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Although pulmonary vein isolation (PVI) gaps and extrapulmonary vein triggers contribute to recurrence after atrial fibrillation (AF) ablation, their precise mechanisms remain unproven. Our study assessed the impact of PVI gaps on rhythm outcomes using a human AF digital twin. We included 50 patients (76.0% with persistent AF) who underwent catheter ablation with a realistic AF digital twin by integrating computed tomography and electroanatomical mapping. We evaluated the final rhythm status, including AF and atrial tachycardia (AT), across 600 AF episodes, considering factors including PVI level, PVI gap number, and pacing locations. Our findings revealed that antral PVI had a significantly lower ratio of AF at the final rhythm (28% vs. 56%, p = 0.002) than ostial PVI. Increasing PVI gap numbers correlated with an increased ratio of AF at the final rhythm (p < 0.001). Extra-PV induction yielded a higher ratio of AF at the final rhythm than internal PV induction (77.5% vs. 59.0%, p < 0.001). In conclusion, our human AF digital twin model helped assess AF maintenance mechanisms. Clinical trial registration: https://www.clinicaltrials.gov; Unique identifier: NCT02138695.

Original languageEnglish
Article number81
Journalnpj Digital Medicine
Volume7
Issue number1
DOIs
Publication statusPublished - 2024 Dec

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Health Informatics
  • Computer Science Applications
  • Health Information Management

Fingerprint

Dive into the research topics of 'Anti- and pro-fibrillatory effects of pulmonary vein isolation gaps in human atrial fibrillation digital twins'. Together they form a unique fingerprint.

Cite this