Analysis of the hemispheric asymmetry using fractal dimension of a skeletonized cerebral surface

Jong Min Lee; Uicheul Yoon; Jae Jin Kim; In Young Kim; Dong Soo Lee; Jun Soo Kwon; Sun I. Kim

doi:10.1109/TBME.2004.831543

Analysis of the hemispheric asymmetry using fractal dimension of a skeletonized cerebral surface

Jong Min Lee, Uicheul Yoon, Jae Jin Kim, In Young Kim, Dong Soo Lee, Jun Soo Kwon, Sun I. Kim

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We investigated hemispheric asymmetry using the fractal dimension (FD) of the skeletonized cerebral surface. Sicty-two T1-weighted magnetic resonance imaging volumes from normal Korean adults were used. The skeletonization of binary volume data, which corresponded to the union of the gray matter and cerebrospinal flow classified by fuzzy clustering, was performed slice by slice in the sagittal direction, and then skeletonized slices were integrated into the three-dimensional (3-D) hemisphere. Finally, the FD of the 3-D skeletonized cerebral surface was calculated using the box-counting method. We measured the FD of the skeletonized cerebral surface and the volumes of intracranial gray matter and white matter for the whole hemispheres and obtained the hemispheric asymmetries of each measurement. The FD, the gray matter, and the white matter volumes for the whole hemispheres decreased in the old group. The asymmetry of the FD revealed a significant right-greater-than-left asymmetry showed rightward, but did not change according to age and gender. None of the intracranial gray matter or white matter volumes showed any significant asymmetric changes. It could be said that the FD of the skeletonized cerebral surface is a novel measure of cerebral asymmetry.

Original language	English
Pages (from-to)	1494-1498
Number of pages	5
Journal	IEEE Transactions on Biomedical Engineering
Volume	51
Issue number	8
DOIs	https://doi.org/10.1109/TBME.2004.831543
Publication status	Published - 2004 Aug

Bibliographical note

Funding Information:
Manuscript received July 18, 2003; revised February 22, 2004. This work was supported in part by the Korean Health 21 R&D project, and in part by the Ministry of Health and Welfare, Republic of Korea, under Grant 02-PJ3-PG6-EV07-002. Asterisk indicates corresponding author. J.-M. Lee, U. Yoon, and I. Y. Kim, are with the Department of Biomedical Engineering, Hanyang University, Seoul, 133-605, Korea. J.-J. Kim is with the Department of Psychiatry, Yonsei University College of Medicine, Gyonggi-do 464-100, Korea. D. S. Lee is with the Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110-744, Korea. J. S. Kwon is with the Department of Psychiatry, Seoul National University College of Medicine, Seoul 110-744, Korea. *S. I. Kim is with the Department of Biomedical Engineering, Hanyang University, Seoul, 133-605, Korea (e-mail: sunkim@hanyang.ac.kr). Digital Object Identifier 10.1109/TBME.2004.831543

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Biomedical Engineering

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title = "Analysis of the hemispheric asymmetry using fractal dimension of a skeletonized cerebral surface",

abstract = "We investigated hemispheric asymmetry using the fractal dimension (FD) of the skeletonized cerebral surface. Sicty-two T1-weighted magnetic resonance imaging volumes from normal Korean adults were used. The skeletonization of binary volume data, which corresponded to the union of the gray matter and cerebrospinal flow classified by fuzzy clustering, was performed slice by slice in the sagittal direction, and then skeletonized slices were integrated into the three-dimensional (3-D) hemisphere. Finally, the FD of the 3-D skeletonized cerebral surface was calculated using the box-counting method. We measured the FD of the skeletonized cerebral surface and the volumes of intracranial gray matter and white matter for the whole hemispheres and obtained the hemispheric asymmetries of each measurement. The FD, the gray matter, and the white matter volumes for the whole hemispheres decreased in the old group. The asymmetry of the FD revealed a significant right-greater-than-left asymmetry showed rightward, but did not change according to age and gender. None of the intracranial gray matter or white matter volumes showed any significant asymmetric changes. It could be said that the FD of the skeletonized cerebral surface is a novel measure of cerebral asymmetry.",

author = "Lee, {Jong Min} and Uicheul Yoon and Kim, {Jae Jin} and Kim, {In Young} and Lee, {Dong Soo} and Kwon, {Jun Soo} and Kim, {Sun I.}",

note = "Funding Information: Manuscript received July 18, 2003; revised February 22, 2004. This work was supported in part by the Korean Health 21 R&D project, and in part by the Ministry of Health and Welfare, Republic of Korea, under Grant 02-PJ3-PG6-EV07-002. Asterisk indicates corresponding author. J.-M. Lee, U. Yoon, and I. Y. Kim, are with the Department of Biomedical Engineering, Hanyang University, Seoul, 133-605, Korea. J.-J. Kim is with the Department of Psychiatry, Yonsei University College of Medicine, Gyonggi-do 464-100, Korea. D. S. Lee is with the Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110-744, Korea. J. S. Kwon is with the Department of Psychiatry, Seoul National University College of Medicine, Seoul 110-744, Korea. *S. I. Kim is with the Department of Biomedical Engineering, Hanyang University, Seoul, 133-605, Korea (e-mail: sunkim@hanyang.ac.kr). Digital Object Identifier 10.1109/TBME.2004.831543",

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AU - Kim, In Young

AU - Lee, Dong Soo

AU - Kwon, Jun Soo

AU - Kim, Sun I.

N1 - Funding Information: Manuscript received July 18, 2003; revised February 22, 2004. This work was supported in part by the Korean Health 21 R&D project, and in part by the Ministry of Health and Welfare, Republic of Korea, under Grant 02-PJ3-PG6-EV07-002. Asterisk indicates corresponding author. J.-M. Lee, U. Yoon, and I. Y. Kim, are with the Department of Biomedical Engineering, Hanyang University, Seoul, 133-605, Korea. J.-J. Kim is with the Department of Psychiatry, Yonsei University College of Medicine, Gyonggi-do 464-100, Korea. D. S. Lee is with the Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110-744, Korea. J. S. Kwon is with the Department of Psychiatry, Seoul National University College of Medicine, Seoul 110-744, Korea. *S. I. Kim is with the Department of Biomedical Engineering, Hanyang University, Seoul, 133-605, Korea (e-mail: sunkim@hanyang.ac.kr). Digital Object Identifier 10.1109/TBME.2004.831543

PY - 2004/8

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N2 - We investigated hemispheric asymmetry using the fractal dimension (FD) of the skeletonized cerebral surface. Sicty-two T1-weighted magnetic resonance imaging volumes from normal Korean adults were used. The skeletonization of binary volume data, which corresponded to the union of the gray matter and cerebrospinal flow classified by fuzzy clustering, was performed slice by slice in the sagittal direction, and then skeletonized slices were integrated into the three-dimensional (3-D) hemisphere. Finally, the FD of the 3-D skeletonized cerebral surface was calculated using the box-counting method. We measured the FD of the skeletonized cerebral surface and the volumes of intracranial gray matter and white matter for the whole hemispheres and obtained the hemispheric asymmetries of each measurement. The FD, the gray matter, and the white matter volumes for the whole hemispheres decreased in the old group. The asymmetry of the FD revealed a significant right-greater-than-left asymmetry showed rightward, but did not change according to age and gender. None of the intracranial gray matter or white matter volumes showed any significant asymmetric changes. It could be said that the FD of the skeletonized cerebral surface is a novel measure of cerebral asymmetry.

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Analysis of the hemispheric asymmetry using fractal dimension of a skeletonized cerebral surface

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