An open label, multicenter, phase II study of dovitinib in advanced thyroid cancer

Sun Min Lim, Woong Youn Chung, Kee Hyun Nam, Sang Wook Kang, Jae Yun Lim, Hoon Gu Kim, Seong Hoon Shin, Jong Mu Sun, Seong Geun Kim, Joo Hang Kim, Chan Woo Kang, Hye Ryun Kim, Byoung Chul Cho

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35 Citations (Scopus)


Abstract Background This phase 2 study investigated the efficacy and safety of dovitinib (TKI258), a receptor tyrosine kinase inhibitor with potent activity against fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR), in locally advanced or metastatic thyroid cancer patients. Patients and methods Patients with advanced thyroid cancer that was refractory or not appropriate for 131I received dovitinib orally, 500 mg once daily for five consecutive days, followed by a 2-day rest every week. The primary end-point was objective response rate. Secondary end-points were progression-free survival (PFS), overall survival (OS), duration of response, changes in tumour markers and safety. Results Between January 2013 and October 2014, a total of 40 patients were enrolled. There were 23 (57.5%) papillary thyroid cancer, 12 (30%) medullary thyroid cancer and 5 (12.5%) follicular thyroid cancer patients. One patient had withdrawn consent before the administration of dovitinib. The overall response rate was 20.5% (8/39) and disease control rate was 69.1% (26/39). Median PFS was 5.4 months (95% confidence interval (CI), 2.0-8.8) and median OS was not reached with 8.4 months follow-up duration. Common treatment-related adverse events were diarrhoea (53.8%), anorexia (35.8%), vomiting (25.6%), fatigue (23%) and nausea (20.5%), most of which were grade 1 or 2. There were no grade 4 events or treatment-related deaths. Dose interruption occurred in 12 (30.7%) patients, and 19 (48.7%) patients experienced dose reduction due to adverse events. Conclusions Dovitinib has a modest activity with manageable toxicity in locally advanced or metastatic thyroid cancer.

Original languageEnglish
Article number9492
Pages (from-to)1588-1595
Number of pages8
JournalEuropean Journal of Cancer
Issue number12
Publication statusPublished - 2015 Jul 9

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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