An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar

Yam Prasad Aryal, Sanjiv Neupane, Nirpesh Adhikari, Chang Hyeon An, Jung Hong Ha, Tae Yub Kwon, Hitoshi Yamamoto, Jae Kwang Jung, Eui Kyun Park, Ji Youn Kim, Sung Won Cho, Wern Joo Sohn, Youngkyun Lee, Han Jung Chae, Hyung Ryong Kim, Jae Young Kim

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6 Citations (Scopus)


To understand the role of endoplasmic reticulum (ER)-stress in mice molar development, we studied Tmbim6 that antagonizes the unfolded protein response, using Tmbim6 knockout (KO) mice and in vitro organ cultivation with knocking down using small interfering RNA. During molar development, Tmbim6 is expressed in developing tooth at E14–E16, postnatal0 (PN0), and PN6. Mineral content in Tmbim6 KO enamel was reduced while dentin was slightly increased revealing ultrastructural changes in pattern formation of both enamel and dentin. Moreover, odontoblast differentiation was altered with increased Dspp expression at PN0 followed by altered AMELX localizations at PN5. These results were confirmed by in vitro organ cultivation and showed altered Bmp signaling, proliferation, and actin rearrangement in the presumptive ameloblast and odontoblasts that followed the altered expression of differentiation and ER stress-related signaling molecules at E16.5. Overall, ER stress modulated by Tmbim6 would play important roles in patterned dental hard tissue formation in mice molar within a limited period of development.

Original languageEnglish
Pages (from-to)20354-20365
Number of pages12
JournalJournal of Cellular Physiology
Issue number11
Publication statusPublished - 2019 Nov

Bibliographical note

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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