Amorphous calcium polyphosphate bone regenerative materials based on calcium phosphate glass

Byung Hyun Lee, Min Chul Kim, Seong Ho Choi, Young Keun Lee

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


We developed new calcium phosphate bone substitute material, amorphous calcium polyphosphate. The new material is synthesized by a cement-like slif-setting reaction with calcium phosphate glass, basic materials and water. In this study, we prepared with CPG, Na2CO3 and NaOH solution. When they are mixed together, amorphous phase was precipitated. The precipitated amorphous phase consisted of polyphosphate chains condensed with Na ions released from Na2CO3 and NaOH. When the amorphous calcium polyphosphate dissolves, inorganic polyphosphates are released into the medium. The inorganic polyphosphates as the dissolution product inducted the calcification of the osteoblast cells. Therefore, in animal test, the new bone formation in rat calvarial defects treated with the new material was significantly higher than sham-surgery control group, especially in the initial stage. The amorphous calcium polyphosphate was biocompatible and bioresorbable and promoted the new bone formation.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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