Amorolfine nail lacquer 5% once weekly in onychomycosis of fingers and/or toes

H. C. Eun, M. H. Lee, S. N. Kim, H. J. Yoo, K. S. Kwon, S. C. Kim, J. S. Lee, B. S. Kim, B. S. Chung, S. H. Chang, C. W. Park, K. J. Kim, J. H. Lee

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1 Citation (Scopus)


Background: Amorolfine is a new topical antifungal drug of the morpholine class which has broad spectrum fungicidal activity. Amorolfine nail lacquer 5% is a transungual delivery system which can penetrate well through the nail plate to the infected keratin and remain there for a prolonged period. Objective: The aim of this study is to assess the efficacy and tolerability of 5% amerolfine nail lacquer given once weekly to the patients with onychomycosis. Methods: 29 patients with onychomycosis affecting not more than 80% of the surface of nail were treated once weekly for up to 9 months with amorolfine nail lacquer 5%. Clinical and mycological examination were performed before treatment and 3, 6, 9 months after start of treatment. Final evaluation was done 3 months after the end of treatment. Results: Average affected area (%) and average score of clinical signs - thickening, splitting, discoloration - were significantly decreased 3 months after start of treatment. Mycological cure rate was continuously increased according to the treatment duration reaching 75.9% at 3 months after treatment. Overall efficacy assessed by the investgators were cure in 31.0% and improvement in 41.4%. Tolerability, mode and frequency of treatment, and formulation were evaluated as good or excellent by most of the patients. No systemic or local side effect was observed. Conclusion: Amorolfine nail lacquer 5% used once weekly up to 9 months was relatively effective and safe for the treatment of onychomycosis.

Original languageEnglish
Pages (from-to)314-321
Number of pages8
JournalKorean Journal of Dermatology
Issue number2
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Dermatology


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