Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation

Ji Hun Byun, Hye Yun Kim, Young Soo Kim, Inhee Mook-Jung, Dong Jin Kim, Won Koo Lee, Kyung Ho Yoo

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65 Citations (Scopus)


The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 μM, respectively) than those of Curcumin (IC50 = 0.80 μM) and IMSB (IC50 = 8.00 μM) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation.

Original languageEnglish
Pages (from-to)5591-5593
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number20
Publication statusPublished - 2008 Oct 15

Bibliographical note

Funding Information:
We are grateful to the Ministry of Science and Technology (MOST) and Ministry of Commerce, Industry and Energy (MCIE) of Korea for financial support.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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