Amide proton transfer imaging for differentiation of benign and atypical meningiomas

Bio Joo; Kyunghwa Han; Yoon Seong Choi; Seung Koo Lee; Sung Soo Ahn; Jong Hee Chang; Seok Gu Kang; Se Hoon Kim; Jinyuan Zhou

doi:10.1007/s00330-017-4962-1

Amide proton transfer imaging for differentiation of benign and atypical meningiomas

Bio Joo, Kyunghwa Han, Yoon Seong Choi, Seung Koo Lee, Sung Soo Ahn, Jong Hee Chang, Seok Gu Kang, Se Hoon Kim, Jinyuan Zhou

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose: To investigate the difference in amide proton transfer (APT)-weighted signals between benign and atypical meningiomas and determine the value of APT imaging for differentiating the two. Methods: Fifty-seven patients with pathologically diagnosed meningiomas (benign, 44; atypical, 13), who underwent preoperative MRI with APT imaging between December 2014 and August 2016 were included. We compared normalised magnetisation transfer ratio asymmetry (nMTR_asym) values between benign and atypical meningiomas on APT-weighted images. Conventional MRI features were qualitatively assessed. Both imaging features were evaluated by multivariable logistic regression analysis. The discriminative value of MRI with and without nMTR_asym was evaluated. Results: The nMTR_asym of atypical meningiomas was significantly greater than that of benign meningiomas (2.46% vs. 1.67%; P < 0.001). In conventional MR images, benign and atypical meningiomas exhibited significant differences in maximum tumour diameter, non-skull base location, and heterogeneous enhancement. On multivariable logistic regression analysis, high nMTR_asym was an independent predictor of atypical meningiomas (adjusted OR, 11.227; P = 0.014). The diagnostic performance of MRI improved with nMTR_asym for predicting atypical meningiomas. Conclusion: Atypical meningiomas exhibited significantly higher APT-weighted signal intensities than benign meningiomas. The discriminative value of conventional MRI improved significantly when combined with APT imaging for diagnosis of atypical meningioma. Key Points: • APT imaging is useful for differentiating between atypical and benign meningiomas. • Atypical meningiomas exhibited high APT-weighted signal intensity than benign meningiomas. • The diagnostic performance of MRI improved with nMTR_asymfor predicting atypical meningiomas.

Original language	English
Pages (from-to)	331-339
Number of pages	9
Journal	European Radiology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1007/s00330-017-4962-1
Publication status	Published - 2018 Jan 1

Bibliographical note

Funding Information:
The authors thank Ha-Kyu Jeong (Korea Basic Science Institute, Chungcheongbuk-do, Korea) for his valuable suggestions and help with protocol optimisation. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by the Ministry of Science, ICT & Future Planning (2014R1A1A1002716), and faculty research grants of the Yonsei University College of Medicine (6-2015-0079), and National Institutes of Health (P41 EB015909, R01 CA166171, and R01 EB009731).

Funding Information:
Funding This study has received funding by the Ministry of Science, ICT & Future Planning (2014R1A1A1002716), and faculty research grants of the Yonsei University College of Medicine (6-2015-0079), and National Institutes of Health (P41 EB015909, R01 CA166171, and R01 EB009731).

Publisher Copyright:
© 2017, European Society of Radiology.

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1007/s00330-017-4962-1

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title = "Amide proton transfer imaging for differentiation of benign and atypical meningiomas",

abstract = "Purpose: To investigate the difference in amide proton transfer (APT)-weighted signals between benign and atypical meningiomas and determine the value of APT imaging for differentiating the two. Methods: Fifty-seven patients with pathologically diagnosed meningiomas (benign, 44; atypical, 13), who underwent preoperative MRI with APT imaging between December 2014 and August 2016 were included. We compared normalised magnetisation transfer ratio asymmetry (nMTRasym) values between benign and atypical meningiomas on APT-weighted images. Conventional MRI features were qualitatively assessed. Both imaging features were evaluated by multivariable logistic regression analysis. The discriminative value of MRI with and without nMTRasym was evaluated. Results: The nMTRasym of atypical meningiomas was significantly greater than that of benign meningiomas (2.46% vs. 1.67%; P < 0.001). In conventional MR images, benign and atypical meningiomas exhibited significant differences in maximum tumour diameter, non-skull base location, and heterogeneous enhancement. On multivariable logistic regression analysis, high nMTRasym was an independent predictor of atypical meningiomas (adjusted OR, 11.227; P = 0.014). The diagnostic performance of MRI improved with nMTRasym for predicting atypical meningiomas. Conclusion: Atypical meningiomas exhibited significantly higher APT-weighted signal intensities than benign meningiomas. The discriminative value of conventional MRI improved significantly when combined with APT imaging for diagnosis of atypical meningioma. Key Points: • APT imaging is useful for differentiating between atypical and benign meningiomas. • Atypical meningiomas exhibited high APT-weighted signal intensity than benign meningiomas. • The diagnostic performance of MRI improved with nMTRasymfor predicting atypical meningiomas.",

author = "Bio Joo and Kyunghwa Han and Choi, {Yoon Seong} and Lee, {Seung Koo} and Ahn, {Sung Soo} and Chang, {Jong Hee} and Kang, {Seok Gu} and Kim, {Se Hoon} and Jinyuan Zhou",

note = "Funding Information: The authors thank Ha-Kyu Jeong (Korea Basic Science Institute, Chungcheongbuk-do, Korea) for his valuable suggestions and help with protocol optimisation. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by the Ministry of Science, ICT & Future Planning (2014R1A1A1002716), and faculty research grants of the Yonsei University College of Medicine (6-2015-0079), and National Institutes of Health (P41 EB015909, R01 CA166171, and R01 EB009731). Funding Information: Funding This study has received funding by the Ministry of Science, ICT & Future Planning (2014R1A1A1002716), and faculty research grants of the Yonsei University College of Medicine (6-2015-0079), and National Institutes of Health (P41 EB015909, R01 CA166171, and R01 EB009731). Publisher Copyright: {\textcopyright} 2017, European Society of Radiology.",

year = "2018",

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doi = "10.1007/s00330-017-4962-1",

language = "English",

volume = "28",

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T1 - Amide proton transfer imaging for differentiation of benign and atypical meningiomas

AU - Joo, Bio

AU - Han, Kyunghwa

AU - Choi, Yoon Seong

AU - Lee, Seung Koo

AU - Ahn, Sung Soo

AU - Chang, Jong Hee

AU - Kang, Seok Gu

AU - Kim, Se Hoon

AU - Zhou, Jinyuan

N1 - Funding Information: The authors thank Ha-Kyu Jeong (Korea Basic Science Institute, Chungcheongbuk-do, Korea) for his valuable suggestions and help with protocol optimisation. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by the Ministry of Science, ICT & Future Planning (2014R1A1A1002716), and faculty research grants of the Yonsei University College of Medicine (6-2015-0079), and National Institutes of Health (P41 EB015909, R01 CA166171, and R01 EB009731). Funding Information: Funding This study has received funding by the Ministry of Science, ICT & Future Planning (2014R1A1A1002716), and faculty research grants of the Yonsei University College of Medicine (6-2015-0079), and National Institutes of Health (P41 EB015909, R01 CA166171, and R01 EB009731). Publisher Copyright: © 2017, European Society of Radiology.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: To investigate the difference in amide proton transfer (APT)-weighted signals between benign and atypical meningiomas and determine the value of APT imaging for differentiating the two. Methods: Fifty-seven patients with pathologically diagnosed meningiomas (benign, 44; atypical, 13), who underwent preoperative MRI with APT imaging between December 2014 and August 2016 were included. We compared normalised magnetisation transfer ratio asymmetry (nMTRasym) values between benign and atypical meningiomas on APT-weighted images. Conventional MRI features were qualitatively assessed. Both imaging features were evaluated by multivariable logistic regression analysis. The discriminative value of MRI with and without nMTRasym was evaluated. Results: The nMTRasym of atypical meningiomas was significantly greater than that of benign meningiomas (2.46% vs. 1.67%; P < 0.001). In conventional MR images, benign and atypical meningiomas exhibited significant differences in maximum tumour diameter, non-skull base location, and heterogeneous enhancement. On multivariable logistic regression analysis, high nMTRasym was an independent predictor of atypical meningiomas (adjusted OR, 11.227; P = 0.014). The diagnostic performance of MRI improved with nMTRasym for predicting atypical meningiomas. Conclusion: Atypical meningiomas exhibited significantly higher APT-weighted signal intensities than benign meningiomas. The discriminative value of conventional MRI improved significantly when combined with APT imaging for diagnosis of atypical meningioma. Key Points: • APT imaging is useful for differentiating between atypical and benign meningiomas. • Atypical meningiomas exhibited high APT-weighted signal intensity than benign meningiomas. • The diagnostic performance of MRI improved with nMTRasymfor predicting atypical meningiomas.

AB - Purpose: To investigate the difference in amide proton transfer (APT)-weighted signals between benign and atypical meningiomas and determine the value of APT imaging for differentiating the two. Methods: Fifty-seven patients with pathologically diagnosed meningiomas (benign, 44; atypical, 13), who underwent preoperative MRI with APT imaging between December 2014 and August 2016 were included. We compared normalised magnetisation transfer ratio asymmetry (nMTRasym) values between benign and atypical meningiomas on APT-weighted images. Conventional MRI features were qualitatively assessed. Both imaging features were evaluated by multivariable logistic regression analysis. The discriminative value of MRI with and without nMTRasym was evaluated. Results: The nMTRasym of atypical meningiomas was significantly greater than that of benign meningiomas (2.46% vs. 1.67%; P < 0.001). In conventional MR images, benign and atypical meningiomas exhibited significant differences in maximum tumour diameter, non-skull base location, and heterogeneous enhancement. On multivariable logistic regression analysis, high nMTRasym was an independent predictor of atypical meningiomas (adjusted OR, 11.227; P = 0.014). The diagnostic performance of MRI improved with nMTRasym for predicting atypical meningiomas. Conclusion: Atypical meningiomas exhibited significantly higher APT-weighted signal intensities than benign meningiomas. The discriminative value of conventional MRI improved significantly when combined with APT imaging for diagnosis of atypical meningioma. Key Points: • APT imaging is useful for differentiating between atypical and benign meningiomas. • Atypical meningiomas exhibited high APT-weighted signal intensity than benign meningiomas. • The diagnostic performance of MRI improved with nMTRasymfor predicting atypical meningiomas.

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Amide proton transfer imaging for differentiation of benign and atypical meningiomas

Abstract

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