Alternative Wnt Signaling Activates YAP/TAZ

Hyun Woo Park, Young Chul Kim, Bo Yu, Toshiro Moroishi, Jung Soon Mo, Steven W. Plouffe, Zhipeng Meng, Kimberly C. Lin, Fa Xing Yu, Caroline M. Alexander, Cun Yu Wang, Kun Liang Guan

Research output: Contribution to journalArticlepeer-review

494 Citations (Scopus)


Summary The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation independent of canonical Wnt/β-catenin signaling. Mechanistically, we delineate the "alternative Wnt-YAP/TAZ signaling axis" that consists of Wnt-FZD/ROR-Gα12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TEAD-mediated transcription. YAP/TAZ mediate the biological functions of alternative Wnt signaling, including gene expression, osteogenic differentiation, cell migration, and antagonism of Wnt/β-catenin signaling. Together, our work establishes YAP/TAZ as critical mediators of alternative Wnt signaling.

Original languageEnglish
Article number8328
Pages (from-to)780-794
Number of pages15
Issue number4
Publication statusPublished - 2015 Aug 17

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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