Alpha-fetoprotein-producing gastric cancer

Ruth Lee, Sun Young Rha, Joong Bae Ahn, Kwang Yong Shim, Jin Hyuk Choi, H. O. Young Lim, Nae Choon Yoo, Sung Hoon Noh, Joo Hang Kim, Jae Kyung Roh, Jin Sik Min, Byung Soo Kim, Hyun Cheol Chung

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We measured the sero-positivity rate of serum α-fetoprotein (αFP) of gastric cancer patients by ELISA assay; forty-two curatively resected patients, 14 palliatively resected patients, 8 who received explo-laparotomy or bypass surgery and 18 patients with systemic metastasis. The sero-positive rate was 9.8% (8/82) and the positivity increased with cancer progression. Sex, age and pathological type were similar between αFP-positive and - negative patients. The overall synchronous hepatic metastasis rates in αFP- positive and αFP-negative groups were 37.5% (3/8) and 12.2% (9/74), respectively (p=0.08). The predictability of synchronous liver metastasis in eight αFP-positive patients were as follows: 37.5% of total patients (3/8), 50.0% (3/6) of unresectable patients, and 60.0% (3/5) of patients with systemic metastasis. In three αFP-positive patient with liver metastasis, all the hepatic lesions were intrahepatic and multiple, while in αFP- negative patients, 67% (6/9) of the hepatic lesions was single intrahepatic lesion or surface nodule. The predictability of both synchronous and metachronous liver metastasis in αFP-positive gastric cancer patients was 75%. These findings suggested that, in advanced stomach cancer patients, especially in stage IV, αFP can be used in predicting liver metastasis during follow-up.

Original languageEnglish
Pages (from-to)1179-1184
Number of pages6
JournalOncology reports
Issue number5
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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