Age-related epigenetic regulation in the brain and its role in neuronal diseases

Jeongsil Kim-Ha, Young Joon Kim

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Accumulating evidence indicates many brain functions are mediated by epigenetic regulation of neural genes, and their dysregulations result in neuronal disorders. Experiences such as learning and recall, as well as physical exercise, induce neuronal activation through epigenetic modifications and by changing the noncoding RNA profiles. Animal models, brain samples from patients, and the development of diverse analytical methods have broadened our understanding of epigenetic regulation in the brain. Diverse and specific epigenetic changes are suggested to correlate with neuronal development, learning and memory, aging and age-related neuronal diseases. Although the results show some discrepancies, a careful comparison of the data (including methods, regions and conditions examined) would clarify the problems confronted in understanding epigenetic regulation in the brain.

Original languageEnglish
Pages (from-to)671-680
Number of pages10
JournalBMB reports
Issue number12
Publication statusPublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 by the The Korean Society for Biochemistry and Molecular Biology.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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