Adjuvant effect of polyadenylic.Polyuridylic acid on antibody production of recombinant hepatitis B surface antigen in mice

Sang Jin Park; Won Ho Kim; Kwang Hyub Han; Chae Yoon Chon; Ki Baik Hahm; Young Myoung Moon; Jin Kyung Kang; In Suh Park; Jung Koo Youn

doi:10.1016/0192-0561(95)00031-V

Adjuvant effect of polyadenylic.Polyuridylic acid on antibody production of recombinant hepatitis B surface antigen in mice

Sang Jin Park, Won Ho Kim, Kwang Hyub Han, Chae Yoon Chon, Ki Baik Hahm, Young Myoung Moon, Jin Kyung Kang, In Suh Park, Jung Koo Youn

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The adjuvant effect of polyadenylic.polyuridylic acid [poly(A).poly(U)] on antibody production against recombinant hepatitis B surface antigen (rHBsAg) was investigated. Immunization of adult Balb/c mice with rHBsAg plus poly(A).poly(U) elicited significantly higher antibody responses than immunization of mice immunized with rHBsAg alone. Such an adjuvant effect was evident even in mice sensitized with subimmunogenic doses of the antigen.

Original language	English
Pages (from-to)	513-516
Number of pages	4
Journal	International Journal of Immunopharmacology
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/0192-0561(95)00031-V
Publication status	Published - 1995 Jun

All Science Journal Classification (ASJC) codes

Immunology
Pharmacology

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10.1016/0192-0561(95)00031-V

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title = "Adjuvant effect of polyadenylic.Polyuridylic acid on antibody production of recombinant hepatitis B surface antigen in mice",

abstract = "The adjuvant effect of polyadenylic.polyuridylic acid [poly(A).poly(U)] on antibody production against recombinant hepatitis B surface antigen (rHBsAg) was investigated. Immunization of adult Balb/c mice with rHBsAg plus poly(A).poly(U) elicited significantly higher antibody responses than immunization of mice immunized with rHBsAg alone. Such an adjuvant effect was evident even in mice sensitized with subimmunogenic doses of the antigen.",

author = "Park, {Sang Jin} and Kim, {Won Ho} and Han, {Kwang Hyub} and Chon, {Chae Yoon} and Hahm, {Ki Baik} and Moon, {Young Myoung} and Kang, {Jin Kyung} and Park, {In Suh} and Youn, {Jung Koo}",

year = "1995",

month = jun,

doi = "10.1016/0192-0561(95)00031-V",

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T1 - Adjuvant effect of polyadenylic.Polyuridylic acid on antibody production of recombinant hepatitis B surface antigen in mice

AU - Park, Sang Jin

AU - Kim, Won Ho

AU - Han, Kwang Hyub

AU - Chon, Chae Yoon

AU - Hahm, Ki Baik

AU - Moon, Young Myoung

AU - Kang, Jin Kyung

AU - Park, In Suh

AU - Youn, Jung Koo

PY - 1995/6

Y1 - 1995/6

N2 - The adjuvant effect of polyadenylic.polyuridylic acid [poly(A).poly(U)] on antibody production against recombinant hepatitis B surface antigen (rHBsAg) was investigated. Immunization of adult Balb/c mice with rHBsAg plus poly(A).poly(U) elicited significantly higher antibody responses than immunization of mice immunized with rHBsAg alone. Such an adjuvant effect was evident even in mice sensitized with subimmunogenic doses of the antigen.

AB - The adjuvant effect of polyadenylic.polyuridylic acid [poly(A).poly(U)] on antibody production against recombinant hepatitis B surface antigen (rHBsAg) was investigated. Immunization of adult Balb/c mice with rHBsAg plus poly(A).poly(U) elicited significantly higher antibody responses than immunization of mice immunized with rHBsAg alone. Such an adjuvant effect was evident even in mice sensitized with subimmunogenic doses of the antigen.

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ER -

Adjuvant effect of polyadenylic.Polyuridylic acid on antibody production of recombinant hepatitis B surface antigen in mice

Abstract

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