TY - JOUR
T1 - Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging
AU - Park, Byung Soon
AU - Jang, Kyoung Ae
AU - Sung, Jong Hyuk
AU - Park, Jeong Soo
AU - Kwon, Yong Hyun
AU - Kim, Kea Jeong
AU - Kim, Won Serk
PY - 2008/10
Y1 - 2008/10
N2 - BACKGROUND: Adipose-derived stem cells (ADSCs) and their secretory factors can stimulate collagen synthesis and migration of fibroblasts during the wound healing process. Conventional treatments for skin aging, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors. Considering the results of our previous study, ADSCs can also be used for the treatment of skin aging. OBJECTIVE: The aim was to verify the effectiveness of ADSCs for the treatment of skin aging. METHODS: We analyzed secretory factors of ADSCs and intradermally injected ADSCs (1 × 106 cells in 1 mL of Hanks' buffered salt solution) and conditioned media of ADSCs on the back of a micropig. In addition, as a pilot study, intradermal injections of purified autologous processed lipoaspirate (PLA) cells were tried with the photoaged skin of one patient. RESULTS: We demonstrated that ADSCs produce many useful growth factors, increase collagen production in animal study, and reverse skin aging in human trial. CONCLUSION: ADSCs and their secretory factors show promise for application in cosmetic dermatology, especially in the treatment of skin aging. The authors have indicated no significant interest with commercial supporters.
AB - BACKGROUND: Adipose-derived stem cells (ADSCs) and their secretory factors can stimulate collagen synthesis and migration of fibroblasts during the wound healing process. Conventional treatments for skin aging, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors. Considering the results of our previous study, ADSCs can also be used for the treatment of skin aging. OBJECTIVE: The aim was to verify the effectiveness of ADSCs for the treatment of skin aging. METHODS: We analyzed secretory factors of ADSCs and intradermally injected ADSCs (1 × 106 cells in 1 mL of Hanks' buffered salt solution) and conditioned media of ADSCs on the back of a micropig. In addition, as a pilot study, intradermal injections of purified autologous processed lipoaspirate (PLA) cells were tried with the photoaged skin of one patient. RESULTS: We demonstrated that ADSCs produce many useful growth factors, increase collagen production in animal study, and reverse skin aging in human trial. CONCLUSION: ADSCs and their secretory factors show promise for application in cosmetic dermatology, especially in the treatment of skin aging. The authors have indicated no significant interest with commercial supporters.
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U2 - 10.1111/j.1524-4725.2008.34283.x
DO - 10.1111/j.1524-4725.2008.34283.x
M3 - Article
C2 - 18616537
AN - SCOPUS:53149087075
SN - 1076-0512
VL - 34
SP - 1323
EP - 1326
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 10
ER -