Adipobiology of diabetes mellitus

M. J. Kim; E. Y. Lee; M. Y. Lee; C. H. Chung

doi:10.2174/187152207780363776

Adipobiology of diabetes mellitus

M. J. Kim, E. Y. Lee, M. Y. Lee, C. H. Chung

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Accumulating basic and clinical studies indicate that adipose tissue cells (adipocytes, matrix cells, stromovascular cells and associated macrophages) synthesize and release multiple signaling proteins collectively termed adipokines. Adipokines regulate a broad spectrum of biological processes, with glucose and lipid metabolism being a key example. This defines a new field of study: adipobiology of type 2 diabetes mellitus. The importance of diabetes-related (diabetogenic) adipokines, with an emphasis on adiponectin, resistin, leptin, angiotensin 11, tumor necrosis factor-α, interleukin-6, and visfatin, is reviewed. Competing of pro- and anti-diabetogenic adipokine-mediated signals may pivotally be involved in the adipobiology of diabetes. This paradigm may reveal further new tools for drug development against diabetes and related disorders.

Original language	English
Pages (from-to)	123-127
Number of pages	5
Journal	Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume	7
Issue number	2
DOIs	https://doi.org/10.2174/187152207780363776
Publication status	Published - 2007 Apr

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/187152207780363776

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abstract = "Accumulating basic and clinical studies indicate that adipose tissue cells (adipocytes, matrix cells, stromovascular cells and associated macrophages) synthesize and release multiple signaling proteins collectively termed adipokines. Adipokines regulate a broad spectrum of biological processes, with glucose and lipid metabolism being a key example. This defines a new field of study: adipobiology of type 2 diabetes mellitus. The importance of diabetes-related (diabetogenic) adipokines, with an emphasis on adiponectin, resistin, leptin, angiotensin 11, tumor necrosis factor-α, interleukin-6, and visfatin, is reviewed. Competing of pro- and anti-diabetogenic adipokine-mediated signals may pivotally be involved in the adipobiology of diabetes. This paradigm may reveal further new tools for drug development against diabetes and related disorders.",

keywords = "Adiponectin, Angiotensin II, Drugs, IL-6, Leptin, Resistin, TNF-α, Visfatin",

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AU - Kim, M. J.

AU - Lee, E. Y.

AU - Lee, M. Y.

AU - Chung, C. H.

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KW - Adiponectin

KW - Angiotensin II

KW - Drugs

KW - IL-6

KW - Leptin

KW - Resistin

KW - TNF-α

KW - Visfatin

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Adipobiology of diabetes mellitus

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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