Active accumulation of spherical analytes on plasmonic hot spots of double-bent Au strip arrays by multiple dip-coating

Jinhyung Lee; Eun Ah You; Do Won Hwang; Shinill Kang; Jung Sub Wi

doi:10.3390/nano9050660

Active accumulation of spherical analytes on plasmonic hot spots of double-bent Au strip arrays by multiple dip-coating

Jinhyung Lee, Eun Ah You, Do Won Hwang, Shinill Kang, Jung Sub Wi

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

To achieve sensitive plasmonic biosensors, it is essential to develop an efficient method for concentrating analytes in hot spots, as well as to develop plasmonic nanostructures for concentrating light. In this study, target analytes were delivered to the surface of double-bent Au strip arrays by a multiple dip-coating method; they were self-aligned in the valleys between neighboring Au strips by capillary forces. As the valleys not only accommodate target analytes but also host strong electromagnetic fields due to the interaction between adjacent strips, sensitive measurement of target analytes was possible by monitoring changes in the wavelength of a localized surface plasmon resonance. Using the proposed plasmonic sensor and target delivery method, the adsorption and saturation of polystyrene beads 100 nm in size on the sensor surface were monitored by the shift of the resonance wavelength. In addition, the pH-dependent stability of exosomes accumulated on the sensor surface was successfully monitored by changing the pH from 7.4 to 4.0.

Original language	English
Article number	660
Journal	Nanomaterials
Volume	9
Issue number	5
DOIs	https://doi.org/10.3390/nano9050660
Publication status	Published - 2019 May

Bibliographical note

Funding Information:
This study was supported by the Korea Research Institute of Standards and Science (Development of Platform Technology for Innovative Medical Measurements [KRISS-2019-GP2019-0013]) and by the National Research Foundation funded by the Ministry of Science and ICT of Korea (Bio and Medical Technology Development Program [2015M3A9D7029894], Global Frontier Project [HGUARD_2013M3A6B2078962], and Nano Material Technology Development Program [2014M3A7B6020163, 2017M3A7B4041754]).

Funding Information:
Funding: This study was supported by the Korea Research Institute of Standards and Science (Development of Platform Technology for Innovative Medical Measurements [KRISS-2019-GP2019-0013]) and by the National Research Foundation funded by the Ministry of Science and ICT of Korea (Bio and Medical Technology Development Program [2015M3A9D7029894], Global Frontier Project [HGUARD_2013M3A6B2078962], and Nano Material Technology Development Program [2014M3A7B6020163, 2017M3A7B4041754]).

Publisher Copyright:
© 2019 by the authors.

All Science Journal Classification (ASJC) codes

Chemical Engineering(all)
Materials Science(all)

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10.3390/nano9050660

Cite this

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title = "Active accumulation of spherical analytes on plasmonic hot spots of double-bent Au strip arrays by multiple dip-coating",

abstract = "To achieve sensitive plasmonic biosensors, it is essential to develop an efficient method for concentrating analytes in hot spots, as well as to develop plasmonic nanostructures for concentrating light. In this study, target analytes were delivered to the surface of double-bent Au strip arrays by a multiple dip-coating method; they were self-aligned in the valleys between neighboring Au strips by capillary forces. As the valleys not only accommodate target analytes but also host strong electromagnetic fields due to the interaction between adjacent strips, sensitive measurement of target analytes was possible by monitoring changes in the wavelength of a localized surface plasmon resonance. Using the proposed plasmonic sensor and target delivery method, the adsorption and saturation of polystyrene beads 100 nm in size on the sensor surface were monitored by the shift of the resonance wavelength. In addition, the pH-dependent stability of exosomes accumulated on the sensor surface was successfully monitored by changing the pH from 7.4 to 4.0.",

author = "Jinhyung Lee and You, {Eun Ah} and Hwang, {Do Won} and Shinill Kang and Wi, {Jung Sub}",

note = "Funding Information: This study was supported by the Korea Research Institute of Standards and Science (Development of Platform Technology for Innovative Medical Measurements [KRISS-2019-GP2019-0013]) and by the National Research Foundation funded by the Ministry of Science and ICT of Korea (Bio and Medical Technology Development Program [2015M3A9D7029894], Global Frontier Project [HGUARD_2013M3A6B2078962], and Nano Material Technology Development Program [2014M3A7B6020163, 2017M3A7B4041754]). Funding Information: Funding: This study was supported by the Korea Research Institute of Standards and Science (Development of Platform Technology for Innovative Medical Measurements [KRISS-2019-GP2019-0013]) and by the National Research Foundation funded by the Ministry of Science and ICT of Korea (Bio and Medical Technology Development Program [2015M3A9D7029894], Global Frontier Project [HGUARD_2013M3A6B2078962], and Nano Material Technology Development Program [2014M3A7B6020163, 2017M3A7B4041754]). Publisher Copyright: {\textcopyright} 2019 by the authors.",

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volume = "9",

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AU - Lee, Jinhyung

AU - You, Eun Ah

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AU - Kang, Shinill

AU - Wi, Jung Sub

N1 - Funding Information: This study was supported by the Korea Research Institute of Standards and Science (Development of Platform Technology for Innovative Medical Measurements [KRISS-2019-GP2019-0013]) and by the National Research Foundation funded by the Ministry of Science and ICT of Korea (Bio and Medical Technology Development Program [2015M3A9D7029894], Global Frontier Project [HGUARD_2013M3A6B2078962], and Nano Material Technology Development Program [2014M3A7B6020163, 2017M3A7B4041754]). Funding Information: Funding: This study was supported by the Korea Research Institute of Standards and Science (Development of Platform Technology for Innovative Medical Measurements [KRISS-2019-GP2019-0013]) and by the National Research Foundation funded by the Ministry of Science and ICT of Korea (Bio and Medical Technology Development Program [2015M3A9D7029894], Global Frontier Project [HGUARD_2013M3A6B2078962], and Nano Material Technology Development Program [2014M3A7B6020163, 2017M3A7B4041754]). Publisher Copyright: © 2019 by the authors.

PY - 2019/5

Y1 - 2019/5

N2 - To achieve sensitive plasmonic biosensors, it is essential to develop an efficient method for concentrating analytes in hot spots, as well as to develop plasmonic nanostructures for concentrating light. In this study, target analytes were delivered to the surface of double-bent Au strip arrays by a multiple dip-coating method; they were self-aligned in the valleys between neighboring Au strips by capillary forces. As the valleys not only accommodate target analytes but also host strong electromagnetic fields due to the interaction between adjacent strips, sensitive measurement of target analytes was possible by monitoring changes in the wavelength of a localized surface plasmon resonance. Using the proposed plasmonic sensor and target delivery method, the adsorption and saturation of polystyrene beads 100 nm in size on the sensor surface were monitored by the shift of the resonance wavelength. In addition, the pH-dependent stability of exosomes accumulated on the sensor surface was successfully monitored by changing the pH from 7.4 to 4.0.

AB - To achieve sensitive plasmonic biosensors, it is essential to develop an efficient method for concentrating analytes in hot spots, as well as to develop plasmonic nanostructures for concentrating light. In this study, target analytes were delivered to the surface of double-bent Au strip arrays by a multiple dip-coating method; they were self-aligned in the valleys between neighboring Au strips by capillary forces. As the valleys not only accommodate target analytes but also host strong electromagnetic fields due to the interaction between adjacent strips, sensitive measurement of target analytes was possible by monitoring changes in the wavelength of a localized surface plasmon resonance. Using the proposed plasmonic sensor and target delivery method, the adsorption and saturation of polystyrene beads 100 nm in size on the sensor surface were monitored by the shift of the resonance wavelength. In addition, the pH-dependent stability of exosomes accumulated on the sensor surface was successfully monitored by changing the pH from 7.4 to 4.0.

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Active accumulation of spherical analytes on plasmonic hot spots of double-bent Au strip arrays by multiple dip-coating

Abstract

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