Activation of monoamine oxidase isotypes by prolonged intake of aluminum in rat brain

Jae Wan Huh, Myung Min Choi, Han Lee Jang, Seung Ju Yang, Jung Kim Mi, Jene Choi, Ho Lee Kwan, Eun Lee Jong, Sung Woo Cho

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14 Citations (Scopus)


Rats were fed 100 μM aluminum maltolate for one year in their drinking water. Brain aluminum contents have increased 4.2-fold in the aluminum-treated group, whereas no significant changes in the body weight, brain weight, and brain protein content were observed. Long-term aluminum feeding induced apoptosis as assessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method and showed activatory effects on the catalytic efficiency (kcat/KM) of monoamine oxidase-A and monoamine oxidase-B up to 1.9- and 3.8-fold, respectively. The expression level of monoamine oxidase isotypes on the Western blot remained unchanged between the two groups, suggesting a change in post-translational regulation of the activities of monoamine oxidase isotypes by long-term aluminum feeding.

Original languageEnglish
Pages (from-to)2088-2091
Number of pages4
JournalJournal of Inorganic Biochemistry
Issue number10
Publication statusPublished - 2005 Oct

Bibliographical note

Funding Information:
This work was supported by Grants from the Korea Research Foundation (KRF-2002-005-E00002 and KRF-2004-005-C00008) to S.-W. Cho.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Inorganic Chemistry


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