Abstract
Purpose: The objective of this study was to determine the effectiveness of collagenated biphasic calcium phosphate (CBCP) as a carrier for bone morphogenetic protein-2 (BMP-2) at the early stage of healing in rabbit sinus. Material and Methods: In 16 rabbits, BMP-2-loaded CBCP was grafted into one sinus (the BMP group) and saline-soaked CBCP was grafted into another sinus (the CTL group). The groups were assigned randomly. After 2 weeks (n=8) or 4 weeks (n=8), radiographic and histological analysis was performed. Results: Total augmented volume was significantly larger in the BMP group at both healing periods. Furthermore, new bone volume was significantly greater in the BMP group at 4 weeks. Marked bone formation near the schneiderian membrane was found in the BMP groups at the early healing period. At 4 weeks, evenly distributed new bone was observed in the BMP group, whereas the new bone was sparsely distributed in the central portion in the CTL group. Conclusion: It can be concluded that the addition of BMP-2 to CBCP resulted in a greater initial augmented volume as a result of postoperative swelling, which is replaced by early bone formation, and it was prominent near the Schneiderian membrane.
Original language | English |
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Pages (from-to) | 1103-1113 |
Number of pages | 11 |
Journal | Clinical Implant Dentistry and Related Research |
Volume | 17 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2015 Dec 1 |
Bibliographical note
Publisher Copyright:© 2015 Wiley Periodicals, Inc.
All Science Journal Classification (ASJC) codes
- Oral Surgery
- General Dentistry