Accelerated 3D myelin water imaging using joint spatio-temporal reconstruction

Jae Hun Lee, Jaeuk Yi, Jun Hyeong Kim, Kanghyun Ryu, Dongyeob Han, Sewook Kim, Seul Lee, Deog Young Kim, Dong Hyun Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose: To enable acceleration in 3D multi-echo gradient echo (mGRE) acquisition for myelin water imaging (MWI) by combining joint parallel imaging (JPI) and joint deep learning (JDL). Methods: We implemented a multistep reconstruction process using both advanced parallel imaging and deep learning network which can utilize joint spatiotemporal components between the multi-echo images to further accelerate 3D mGRE acquisition for MWI. In the first step, JPI was performed to estimate missing k-space lines. Next, JDL was implemented to reduce residual artifacts and produce high-fidelity reconstruction by using variable splitting optimization consisting of spatiotemporal denoiser block, data consistency block, and weighted average block. The proposed method was evaluated for MWI with 2D Cartesian uniform under-sampling for each echo, enabling scan times of up to approximately 2 min for (Formula presented.) 3D coverage. Results: The proposed method showed acceptable MWI quality with improved quantitative values compared to both JPI and JDL methods individually. The improved performance of the proposed method was demonstrated by the low normalized mean-square error and high-frequency error norm values of the reconstruction with high similarity to the fully sampled MWI. Conclusion: Joint spatiotemporal reconstruction approach by combining JPI and JDL can achieve high acceleration factors for 3D mGRE-based MWI.

Original languageEnglish
Pages (from-to)5929-5942
Number of pages14
JournalMedical physics
Issue number9
Publication statusPublished - 2022 Sept

Bibliographical note

Funding Information:
This work was supported by the Korea Medical Device Development Fund grant funded by the Korean government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, Republic of Korea, the Ministry of Food and Drug Safety) (Project Number: KMDF_PR_20200901_0062, 9991006735) and by the MSIT (Ministry of Science and ICT), Korea, under the ITRC (Information Technology Research Center) support program (IITP‐2020‐2020‐0‐01461) supervised by the IITP (Institute for Information & communications Technology Planning & Evaluation).

Publisher Copyright:
© 2022 American Association of Physicists in Medicine.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Accelerated 3D myelin water imaging using joint spatio-temporal reconstruction'. Together they form a unique fingerprint.

Cite this