Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from mers in south korea

Jun Yong Choi; Jin Ok Oh; Jin Young Ahn; Heun Choi; Jung Ho Kim; Hye Seong; Su Jin Jeong; Nam Su Ku; Joon Sup Yeom; Jae Phil Choi

doi:10.7774/cevr.2019.8.1.86

Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from mers in south korea

Jun Yong Choi, Jin Ok Oh, Jin Young Ahn, Heun Choi, Jung Ho Kim, Hye Seong, Su Jin Jeong, Nam Su Ku, Joon Sup Yeom, Jae Phil Choi

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.

Original language	English
Pages (from-to)	86-88
Number of pages	3
Journal	Clinical and Experimental Vaccine Research
Volume	8
Issue number	1
DOIs	https://doi.org/10.7774/cevr.2019.8.1.86
Publication status	Published - 2019

Bibliographical note

Funding Information:
This work was supported by a faculty research grant of Yonsei University College of Medicine for (6-2015-0153).

Publisher Copyright:
© Korean Vaccine Society.

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Pharmacology
Public Health, Environmental and Occupational Health
Infectious Diseases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7774/cevr.2019.8.1.86

Cite this

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title = "Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from mers in south korea",

abstract = "We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.",

author = "Choi, {Jun Yong} and Oh, {Jin Ok} and Ahn, {Jin Young} and Heun Choi and Kim, {Jung Ho} and Hye Seong and Jeong, {Su Jin} and Ku, {Nam Su} and Yeom, {Joon Sup} and Choi, {Jae Phil}",

note = "Funding Information: This work was supported by a faculty research grant of Yonsei University College of Medicine for (6-2015-0153). Publisher Copyright: {\textcopyright} Korean Vaccine Society.",

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doi = "10.7774/cevr.2019.8.1.86",

language = "English",

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AU - Choi, Jun Yong

AU - Oh, Jin Ok

AU - Ahn, Jin Young

AU - Choi, Heun

AU - Kim, Jung Ho

AU - Seong, Hye

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Yeom, Joon Sup

AU - Choi, Jae Phil

PY - 2019

Y1 - 2019

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Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from mers in south korea

Abstract

Bibliographical note

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UN SDGs

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