Abdominal Aortic Calcification in Living Kidney Donors

Y. E. Yoon, W. K. Han, H. H. Lee, M. Y. Chang, K. H. Huh, D. C. Jung, Y. S. Kim, Y. T. Oh

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Objective This study assesses the association between abdominal aortic calcification (AAC) and renal function of living kidney donors and evaluate AAC as a surrogate marker for nephrosclerosis. Methods Between January 2010 and March 2013, 287 donors who underwent living donor nephrectomy were enrolled. We analyzed computed tomography angiographies and quantified AAC scores by calculating the Agatston score for the abdominal aorta. The donors were stratified into the non-AAC group (AAC score = 0; n = 238) and the AAC group (AAC score >0; n = 49). The relationship between AAC and perioperative estimated glomerular filtration rate was analyzed. For the 180 donors consenting to implantation biopsy, the nephrosclerosis score was defined as the sum of abnormalities, including glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis. Results The mean AAC score was 185.5 ± 263.3 in the AAC group. The AAC group was older than the non-AAC group (51.1 ± 6.1 vs 37.9 ± 11 years; P <.001). Perioperative renal function was not different between the 2 groups. However, among the AAC group, donors with an AAC score of >100 were associated with delayed renal function recovery (P =.035). Donors with AAC were more likely to have glomerulosclerosis (50.0% vs 29.1%; P =.022), tubular atrophy (62.5% vs 33.1%; P =.002), and a higher nephrosclerosis score (P =.002). Conclusions Living donors with an AAC score of >100 require close observation because they have a higher probability of delayed renal function recovery after donation. AAC is associated with nephrosclerosis in healthy adults.

Original languageEnglish
Pages (from-to)720-724
Number of pages5
JournalTransplantation Proceedings
Issue number3
Publication statusPublished - 2016 Apr 1

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation


Dive into the research topics of 'Abdominal Aortic Calcification in Living Kidney Donors'. Together they form a unique fingerprint.

Cite this