A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12

R. A. Spritz; K. M. Strunk; S. T. Lee; J. M. Lu-Kuo; D. C. Ward; D. Le Paslier; M. R. Altherr; T. E. Dorman; D. T. Moir

doi:10.1006/geno.1994.1405

A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12

R. A. Spritz, K. M. Strunk, S. T. Lee, J. M. Lu-Kuo, D. C. Ward, D. Le Paslier, M. R. Altherr, T. E. Dorman, D. T. Moir

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Abstract

We have mapped five genes encoding protein tyrosine kinases (PTKs) to the pericentromeric region of human chromosome 4. PTK4 and TYRO4, which encode nonreceptor intracellular PTKs, are located at 4p12 and 4q13, respectively. The other three genes, PDGFRA, KIT, and KDR, encode type III transmembrane receptor PTKs for known ligands. We have developed a contig of 29 yeast artificial chromosomes (YACs) spanning approximately 2 Mb of DNA at 4q12 that includes PDGFRA, KIT, and KDR, and we have used this YAC contig to map 12 different sequence-tagged sites in this region. PDGFRA, KIT, and KDR thus constitute a cluster of genes at 4q12 encoding closely related type III receptor PTKs. Mutations of the human KIT gene result in piebaldism, an autosomal dominant disorder of melanocyte development.

Original language	English
Pages (from-to)	431-436
Number of pages	6
Journal	Genomics
Volume	22
Issue number	2
DOIs	https://doi.org/10.1006/geno.1994.1405
Publication status	Published - 1994 Jul 15

All Science Journal Classification (ASJC) codes

Genetics

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10.1006/geno.1994.1405

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title = "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12",

abstract = "We have mapped five genes encoding protein tyrosine kinases (PTKs) to the pericentromeric region of human chromosome 4. PTK4 and TYRO4, which encode nonreceptor intracellular PTKs, are located at 4p12 and 4q13, respectively. The other three genes, PDGFRA, KIT, and KDR, encode type III transmembrane receptor PTKs for known ligands. We have developed a contig of 29 yeast artificial chromosomes (YACs) spanning approximately 2 Mb of DNA at 4q12 that includes PDGFRA, KIT, and KDR, and we have used this YAC contig to map 12 different sequence-tagged sites in this region. PDGFRA, KIT, and KDR thus constitute a cluster of genes at 4q12 encoding closely related type III receptor PTKs. Mutations of the human KIT gene result in piebaldism, an autosomal dominant disorder of melanocyte development.",

author = "Spritz, {R. A.} and Strunk, {K. M.} and Lee, {S. T.} and Lu-Kuo, {J. M.} and Ward, {D. C.} and {Le Paslier}, D. and Altherr, {M. R.} and Dorman, {T. E.} and Moir, {D. T.}",

year = "1994",

month = jul,

day = "15",

doi = "10.1006/geno.1994.1405",

language = "English",

volume = "22",

pages = "431--436",

journal = "Genomics",

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T1 - A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12

AU - Spritz, R. A.

AU - Strunk, K. M.

AU - Lee, S. T.

AU - Lu-Kuo, J. M.

AU - Ward, D. C.

AU - Le Paslier, D.

AU - Altherr, M. R.

AU - Dorman, T. E.

AU - Moir, D. T.

PY - 1994/7/15

Y1 - 1994/7/15

N2 - We have mapped five genes encoding protein tyrosine kinases (PTKs) to the pericentromeric region of human chromosome 4. PTK4 and TYRO4, which encode nonreceptor intracellular PTKs, are located at 4p12 and 4q13, respectively. The other three genes, PDGFRA, KIT, and KDR, encode type III transmembrane receptor PTKs for known ligands. We have developed a contig of 29 yeast artificial chromosomes (YACs) spanning approximately 2 Mb of DNA at 4q12 that includes PDGFRA, KIT, and KDR, and we have used this YAC contig to map 12 different sequence-tagged sites in this region. PDGFRA, KIT, and KDR thus constitute a cluster of genes at 4q12 encoding closely related type III receptor PTKs. Mutations of the human KIT gene result in piebaldism, an autosomal dominant disorder of melanocyte development.

AB - We have mapped five genes encoding protein tyrosine kinases (PTKs) to the pericentromeric region of human chromosome 4. PTK4 and TYRO4, which encode nonreceptor intracellular PTKs, are located at 4p12 and 4q13, respectively. The other three genes, PDGFRA, KIT, and KDR, encode type III transmembrane receptor PTKs for known ligands. We have developed a contig of 29 yeast artificial chromosomes (YACs) spanning approximately 2 Mb of DNA at 4q12 that includes PDGFRA, KIT, and KDR, and we have used this YAC contig to map 12 different sequence-tagged sites in this region. PDGFRA, KIT, and KDR thus constitute a cluster of genes at 4q12 encoding closely related type III receptor PTKs. Mutations of the human KIT gene result in piebaldism, an autosomal dominant disorder of melanocyte development.

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DO - 10.1006/geno.1994.1405

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AN - SCOPUS:0028001294

SN - 0888-7543

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JO - Genomics

JF - Genomics

IS - 2

ER -

A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12

Abstract

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