TY - GEN
T1 - A viscoelastic model for nucleus deformation and mechanics in atomic force microscopy indentation
AU - Vaziri, Ashkan
AU - Lee, Hyungsuk
AU - Kamm, Roger D.
AU - Mofrad, Mohammad R.Kaazempur
PY - 2005
Y1 - 2005
N2 - A computational model is developed to simulate the indentation of nucleus with a sharp probe, representing atomic force microscopy (AFM) with conical (sharp) tip. The nucleus model consists of two parts: (i) the nucleoplasm and (ii) the membrane layer representing the nuclear envelope. The nucleoplasm is modeled as a viscoelastic Maxwell material and the nuclear membrane layer is modeled as linear elastic. The overall model is employed to study the mechanical response of the nucleus to various time-dependent indentation loads, and examine the induced stress/strain patterns with different material properties for the nucleus and membrane layer.
AB - A computational model is developed to simulate the indentation of nucleus with a sharp probe, representing atomic force microscopy (AFM) with conical (sharp) tip. The nucleus model consists of two parts: (i) the nucleoplasm and (ii) the membrane layer representing the nuclear envelope. The nucleoplasm is modeled as a viscoelastic Maxwell material and the nuclear membrane layer is modeled as linear elastic. The overall model is employed to study the mechanical response of the nucleus to various time-dependent indentation loads, and examine the induced stress/strain patterns with different material properties for the nucleus and membrane layer.
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M3 - Conference contribution
AN - SCOPUS:33646563705
SN - 0974249211
SN - 9780974249216
T3 - Proceedings of the 2005 Summer Bioengineering Conference
SP - 1108
EP - 1109
BT - Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC
T2 - 2005 Summer Bioengineering Conference
Y2 - 22 June 2005 through 26 June 2005
ER -