Abstract
A highly practical route to oligostilbenoid natural products is described. A regioselective Bi(OTf)3-catalyzed cyclodehydration provided ready access to 3-arylbenzofuran. Pd-catalyzed direct C-H activation of benzofuran and subsequent cross-coupling with aryl halide was successfully implemented for the introduction of aryl group at the C2 position of benzofuran. Further manipulation of the 2,3-diarylbenzofuran led to the efficient total synthesis of permethylated analogues of viniferifuran, malibatol A, and shoreaphenol.
| Original language | English |
|---|---|
| Pages (from-to) | 2788-2795 |
| Number of pages | 8 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 7 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2009 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry