A synthetic DNA walker for molecular transport

Jong Shik Shin, Niles A. Pierce

Research output: Contribution to journalArticlepeer-review

653 Citations (Scopus)


Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.

Original languageEnglish
Pages (from-to)10834-10835
Number of pages2
JournalJournal of the American Chemical Society
Issue number35
Publication statusPublished - 2004 Sept 8

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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