A synthetic DNA walker for molecular transport

Jong Shik Shin; Niles A. Pierce

doi:10.1021/ja047543j

A synthetic DNA walker for molecular transport

Jong Shik Shin, Niles A. Pierce

Research output: Contribution to journal › Article › peer-review

653 Citations (Scopus)

Abstract

Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.

Original language	English
Pages (from-to)	10834-10835
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	35
DOIs	https://doi.org/10.1021/ja047543j
Publication status	Published - 2004 Sept 8

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja047543j

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abstract = "Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.",

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AB - Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.

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A synthetic DNA walker for molecular transport

Abstract

All Science Journal Classification (ASJC) codes

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