A symmetric metamaterial element-based RF biosensor for rapid and label-free detection

Hee Jo Lee, Jung Hyun Lee, Hyo Il Jung

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47 Citations (Scopus)


A symmetric metamaterial element-based RF biosensing scheme is experimentally demonstrated by detecting biomolecular binding between a prostate-specific antigen (PSA) and its antibody. The metamaterial element in a high-impedance microstrip line shows an intrinsic S21 resonance having a Q-factor of 55. The frequency shift with PSA concentration, i.e., 100 ng/ml, 10 ng/ml, and 1 ng/ml, is observed and the changes are δf ≈ 20 MHz, 10 MHz, and 5 MHz, respectively. The proposed biosensor offers advantages of label-free detection, a simple and direct scheme, and cost-efficient fabrication.

Original languageEnglish
Article number163703
JournalApplied Physics Letters
Issue number16
Publication statusPublished - 2011 Oct 17

Bibliographical note

Funding Information:
This study was supported by grants of Ministry of Health and Welfare, Republic of Korea (the National R&D Program for Cancer Control, No. 1120290, the Korea Health technology R&D Project, No. A111114).

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)


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