A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity

Seon Joo Yoon; Yu Ryang Pyun; Jae Kwan Hwang; Paulo A.S. Mourão

doi:10.1016/j.carres.2007.06.019

A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity

Seon Joo Yoon, Yu Ryang Pyun, Jae Kwan Hwang, Paulo A.S. Mourão

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked α-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (∼40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity.

Original language	English
Pages (from-to)	2326-2330
Number of pages	5
Journal	Carbohydrate Research
Volume	342
Issue number	15
DOIs	https://doi.org/10.1016/j.carres.2007.06.019
Publication status	Published - 2007 Nov 5

Bibliographical note

Funding Information:
This investigation was supported in part by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center of Yonsei University.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/j.carres.2007.06.019

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title = "A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity",

abstract = "The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked α-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (∼40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity.",

author = "Yoon, {Seon Joo} and Pyun, {Yu Ryang} and Hwang, {Jae Kwan} and Mour{\~a}o, {Paulo A.S.}",

note = "Funding Information: This investigation was supported in part by grants from Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq), Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado do Rio de Janeiro (FAPERJ) and the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center of Yonsei University.",

year = "2007",

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doi = "10.1016/j.carres.2007.06.019",

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AU - Yoon, Seon Joo

AU - Pyun, Yu Ryang

AU - Hwang, Jae Kwan

AU - Mourão, Paulo A.S.

N1 - Funding Information: This investigation was supported in part by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center of Yonsei University.

PY - 2007/11/5

Y1 - 2007/11/5

N2 - The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked α-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (∼40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity.

AB - The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked α-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (∼40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity.

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SP - 2326

EP - 2330

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 15

ER -

A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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