A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation

Chang Su Kim; Jin Hee Kim; Bokyoung Kim; Young Seok Park; Hong Kyun Kim; Hieu Trung Tran; Sang Hoon Kim; Hojeong Jeon; Sangjib Kim; Ji Hyun Sim; Hyun Mu Shin; Gwanghun Kim; Young Joo Baik; Kee Joon Lee; Hae Young Kim; Tae Jin Yun; Youn Sang Kim; Hang Rae Kim

doi:10.1002/adfm.201703569

A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation

Chang Su Kim, Jin Hee Kim, Bokyoung Kim, Young Seok Park, Hong Kyun Kim, Hieu Trung Tran, Sang Hoon Kim, Hojeong Jeon, Sangjib Kim, Ji Hyun Sim, Hyun Mu Shin, Gwanghun Kim, Young Joo Baik, Kee Joon Lee, Hae Young Kim, Tae Jin Yun, Youn Sang Kim, Hang Rae Kim

Department of Orthodontics

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges (0.35−7 µm) and grooves (0.65−6 µm) of various widths and explored their mechanisms in improving osteoblast differentiation. This study finds that a groove pattern enhancing osteoblast differentiation is associated with the ability of the cell to extend its length and that it is able to overcome the inhibition of osteoblast differentiation that takes place under inflammatory conditions. The groove pattern suppresses the generation of reactive oxygen species, a reaction that is increased in inflammatory conditions. It also modulates the expression of osteogenic factors according to differentiation time. Importantly, specific groove patterns AZ-2 and AZ-4, with ridge width of 2 µm and groove width of 2 or 4 µm, respectively, effectively promote bone regeneration in critical-sized calvarial defects without additional factors. This knowledge of groove patterns can be applied to the development of orthopedic and dental devices.

Original language	English
Article number	1703569
Journal	Advanced Functional Materials
Volume	27
Issue number	44
DOIs	https://doi.org/10.1002/adfm.201703569
Publication status	Published - 2017 Nov 24

Bibliographical note

Funding Information:
C.-S.K., J.-H.K., Y.-S.P., and B.K. contributed equally to this work. The authors thank Prof. Kyung Mi Woo (Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, Republic of Korea) and Tae Hyun Choi (Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea) for their critical discussions and comments. The original manuscript was greatly improved by their comments. This work was supported in part by the Nano-Material Technology Development Program (grant 2014M3A7B4052194 to H.-R.K.); the National Research Foundation of Korea, funded by the Korean government (Ministry of Science, ICT & Future Planning; grant 2015R1C1A2A01051790 to J.-H.K.); and by the Seoul National University Hospital Research Fund (grant 0320140330, 2014-1245 to H.-R.K.). The affiliations section of this article was updated on November 24, 2017 after previous online publication.

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

Chemistry(all)
Materials Science(all)
Condensed Matter Physics

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Kim, C. S., Kim, J. H., Kim, B., Park, Y. S., Kim, H. K., Tran, H. T., Kim, S. H., Jeon, H., Kim, S., Sim, J. H., Shin, H. M., Kim, G., Baik, Y. J., Lee, K. J., Kim, H. Y., Yun, T. J., Kim, Y. S., & Kim, H. R. (2017). A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation. Advanced Functional Materials, 27(44), [1703569]. https://doi.org/10.1002/adfm.201703569

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title = "A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation",

abstract = "Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges (0.35−7 µm) and grooves (0.65−6 µm) of various widths and explored their mechanisms in improving osteoblast differentiation. This study finds that a groove pattern enhancing osteoblast differentiation is associated with the ability of the cell to extend its length and that it is able to overcome the inhibition of osteoblast differentiation that takes place under inflammatory conditions. The groove pattern suppresses the generation of reactive oxygen species, a reaction that is increased in inflammatory conditions. It also modulates the expression of osteogenic factors according to differentiation time. Importantly, specific groove patterns AZ-2 and AZ-4, with ridge width of 2 µm and groove width of 2 or 4 µm, respectively, effectively promote bone regeneration in critical-sized calvarial defects without additional factors. This knowledge of groove patterns can be applied to the development of orthopedic and dental devices.",

author = "Kim, {Chang Su} and Kim, {Jin Hee} and Bokyoung Kim and Park, {Young Seok} and Kim, {Hong Kyun} and Tran, {Hieu Trung} and Kim, {Sang Hoon} and Hojeong Jeon and Sangjib Kim and Sim, {Ji Hyun} and Shin, {Hyun Mu} and Gwanghun Kim and Baik, {Young Joo} and Lee, {Kee Joon} and Kim, {Hae Young} and Yun, {Tae Jin} and Kim, {Youn Sang} and Kim, {Hang Rae}",

note = "Funding Information: C.-S.K., J.-H.K., Y.-S.P., and B.K. contributed equally to this work. The authors thank Prof. Kyung Mi Woo (Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, Republic of Korea) and Tae Hyun Choi (Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea) for their critical discussions and comments. The original manuscript was greatly improved by their comments. This work was supported in part by the Nano-Material Technology Development Program (grant 2014M3A7B4052194 to H.-R.K.); the National Research Foundation of Korea, funded by the Korean government (Ministry of Science, ICT & Future Planning; grant 2015R1C1A2A01051790 to J.-H.K.); and by the Seoul National University Hospital Research Fund (grant 0320140330, 2014-1245 to H.-R.K.). The affiliations section of this article was updated on November 24, 2017 after previous online publication. Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AU - Kim, Chang Su

AU - Kim, Jin Hee

AU - Kim, Bokyoung

AU - Park, Young Seok

AU - Kim, Hong Kyun

AU - Tran, Hieu Trung

AU - Kim, Sang Hoon

AU - Jeon, Hojeong

AU - Kim, Sangjib

AU - Sim, Ji Hyun

AU - Shin, Hyun Mu

AU - Kim, Gwanghun

AU - Baik, Young Joo

AU - Lee, Kee Joon

AU - Kim, Hae Young

AU - Yun, Tae Jin

AU - Kim, Youn Sang

AU - Kim, Hang Rae

N1 - Funding Information: C.-S.K., J.-H.K., Y.-S.P., and B.K. contributed equally to this work. The authors thank Prof. Kyung Mi Woo (Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, Republic of Korea) and Tae Hyun Choi (Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea) for their critical discussions and comments. The original manuscript was greatly improved by their comments. This work was supported in part by the Nano-Material Technology Development Program (grant 2014M3A7B4052194 to H.-R.K.); the National Research Foundation of Korea, funded by the Korean government (Ministry of Science, ICT & Future Planning; grant 2015R1C1A2A01051790 to J.-H.K.); and by the Seoul National University Hospital Research Fund (grant 0320140330, 2014-1245 to H.-R.K.). The affiliations section of this article was updated on November 24, 2017 after previous online publication. Publisher Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2017/11/24

Y1 - 2017/11/24

N2 - Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges (0.35−7 µm) and grooves (0.65−6 µm) of various widths and explored their mechanisms in improving osteoblast differentiation. This study finds that a groove pattern enhancing osteoblast differentiation is associated with the ability of the cell to extend its length and that it is able to overcome the inhibition of osteoblast differentiation that takes place under inflammatory conditions. The groove pattern suppresses the generation of reactive oxygen species, a reaction that is increased in inflammatory conditions. It also modulates the expression of osteogenic factors according to differentiation time. Importantly, specific groove patterns AZ-2 and AZ-4, with ridge width of 2 µm and groove width of 2 or 4 µm, respectively, effectively promote bone regeneration in critical-sized calvarial defects without additional factors. This knowledge of groove patterns can be applied to the development of orthopedic and dental devices.

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ER -

A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation

Abstract

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