A serial occurrence of acute generalized exanthematous pustulosis in childhood siblings

Acute generalized exanthematous pustulosis (AGEP) is clinically characterized by the abrupt onset of erythema, non-follicular superficial pustules, fever and rapid spontaneous healing. Other findings such as peripheral neutrophilia and histologically neutrophilic spongiosis and microabscess also suggest AGEP. Its cause was focused on drug and viral infection, but the latter lacks objective evidence as a causative factor. We report two cases of AGEP that serially occurred in siblings without obvious drug history, which strongly suggests there is a possibility that AGEP could be caused by vital infection.