A selenolactone-based fluorescent chemodosimeter to monitor mecury/methylmercury species in vitro and in vivo

Xiaoqiang Chen; Kyung Hwa Baek; Youngmee Kim; Sung Jin Kim; Injae Shin; Juyoung Yoon

doi:10.1016/j.tet.2010.04.042

A selenolactone-based fluorescent chemodosimeter to monitor mecury/methylmercury species in vitro and in vivo

Xiaoqiang Chen, Kyung Hwa Baek, Youngmee Kim, Sung Jin Kim, Injae Shin, Juyoung Yoon

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

Abstract

A fluorescent probe based on selenolactone displays unique fluorescence enhancement and UV-vis spectral change for mercury/methylmercury species, which were attributed to deselenation reaction. The value of this system was successfully demonstrated by its use in detecting inorganic mercury/methylmercury species in cells and zebrafish.

Original language	English
Pages (from-to)	4016-4021
Number of pages	6
Journal	Tetrahedron
Volume	66
Issue number	23
DOIs	https://doi.org/10.1016/j.tet.2010.04.042
Publication status	Published - 2010 Jun 5

Bibliographical note

Funding Information:
This work was supported by grants from the Korea Research Foundation Grant ( KRF-2006-005-J04002 ), the National Research Foundation of Korea ( NRF ) ( 20090083065 ), the National Creative Research Initiative and WCU ( R32-2008-000-10217-0 ) programs. Mass spectra data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2010.04.042

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abstract = "A fluorescent probe based on selenolactone displays unique fluorescence enhancement and UV-vis spectral change for mercury/methylmercury species, which were attributed to deselenation reaction. The value of this system was successfully demonstrated by its use in detecting inorganic mercury/methylmercury species in cells and zebrafish.",

author = "Xiaoqiang Chen and Baek, {Kyung Hwa} and Youngmee Kim and Kim, {Sung Jin} and Injae Shin and Juyoung Yoon",

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AU - Baek, Kyung Hwa

AU - Kim, Youngmee

AU - Kim, Sung Jin

AU - Shin, Injae

AU - Yoon, Juyoung

N1 - Funding Information: This work was supported by grants from the Korea Research Foundation Grant ( KRF-2006-005-J04002 ), the National Research Foundation of Korea ( NRF ) ( 20090083065 ), the National Creative Research Initiative and WCU ( R32-2008-000-10217-0 ) programs. Mass spectra data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.

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A selenolactone-based fluorescent chemodosimeter to monitor mecury/methylmercury species in vitro and in vivo

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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