A rhodamine-hydroxamic acid-based fluorescent probe for hypochlorous acid and its applications to Biological imagings

Young Keun Yang; Hyungseoph Jason Cho; Jihyun Lee; Injae Shin; Jinsung Tae

doi:10.1021/ol802822t

A rhodamine-hydroxamic acid-based fluorescent probe for hypochlorous acid and its applications to Biological imagings

Young Keun Yang, Hyungseoph Jason Cho, Jihyun Lee, Injae Shin, Jinsung Tae

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

264 Citations (Scopus)

Abstract

A new rhodamine-hydroxamic acid-based fluorescent chemosensor for the rapid detection of HOCl in aqueous media was developed. The system, which utilizes an irreversible HOCl-promoted oxidation reaction, responds instantaneously at room temperature with linear proportionality to the amount of HOCl. This system is highly selective for HOCl over other reactive oxygen species (ROS) and highly sensitive in aqueous solutions. Biological imaging studies using living cells and organisms (A549 cells and zebrafish) to detect HOCl are successfully demonstrated.

Original language	English
Pages (from-to)	859-861
Number of pages	3
Journal	Organic Letters
Volume	11
Issue number	4
DOIs	https://doi.org/10.1021/ol802822t
Publication status	Published - 2009 Feb 19

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol802822t

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abstract = "A new rhodamine-hydroxamic acid-based fluorescent chemosensor for the rapid detection of HOCl in aqueous media was developed. The system, which utilizes an irreversible HOCl-promoted oxidation reaction, responds instantaneously at room temperature with linear proportionality to the amount of HOCl. This system is highly selective for HOCl over other reactive oxygen species (ROS) and highly sensitive in aqueous solutions. Biological imaging studies using living cells and organisms (A549 cells and zebrafish) to detect HOCl are successfully demonstrated.",

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AU - Yang, Young Keun

AU - Cho, Hyungseoph Jason

AU - Lee, Jihyun

AU - Shin, Injae

AU - Tae, Jinsung

PY - 2009/2/19

Y1 - 2009/2/19

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AB - A new rhodamine-hydroxamic acid-based fluorescent chemosensor for the rapid detection of HOCl in aqueous media was developed. The system, which utilizes an irreversible HOCl-promoted oxidation reaction, responds instantaneously at room temperature with linear proportionality to the amount of HOCl. This system is highly selective for HOCl over other reactive oxygen species (ROS) and highly sensitive in aqueous solutions. Biological imaging studies using living cells and organisms (A549 cells and zebrafish) to detect HOCl are successfully demonstrated.

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A rhodamine-hydroxamic acid-based fluorescent probe for hypochlorous acid and its applications to Biological imagings

Abstract

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