A randomized trial to determine the diagnostic accuracy of conventional vs. jumbo forceps biopsy of gastric epithelial neoplasias before endoscopic submucosal dissection; open-label study

Hyo Keun Jeon; Ho Yoel Ryu; Mee Yon Cho; Hyun Soo Kim; Jae Woo Kim; Hong Jun Park; Moon Young Kim; Soon Koo Baik; Sang Ok Kwon; Su Yeon Park; Sung Ho Won

doi:10.1007/s10120-013-0322-2

A randomized trial to determine the diagnostic accuracy of conventional vs. jumbo forceps biopsy of gastric epithelial neoplasias before endoscopic submucosal dissection; open-label study

Hyo Keun Jeon, Ho Yoel Ryu, Mee Yon Cho, Hyun Soo Kim, Jae Woo Kim, Hong Jun Park, Moon Young Kim, Soon Koo Baik, Sang Ok Kwon, Su Yeon Park, Sung Ho Won

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21 Citations (Scopus)

Abstract

Background and aims: Larger biopsy specimens or increasing the number of biopsies may improve the diagnostic accuracy of gastric epithelial neoplasia (GEN). The aims of this study was to compare the diagnostic accuracies between conventional and jumbo forceps biopsy of GEN before endoscopic submucosal dissection (ESD) and to confirm that increasing the number of biopsies is useful for the diagnosis of GEN.

Results: The concordance rate between EFB and ESD specimens was not significantly different between the two groups [83.1 % (54/65) in JG vs. 79.1 % (53/67) in CG]. On multivariate analyses, two or four EFBs significantly increased the cumulating concordance rate [coefficients; twice: 5.1 (P = 0.01), four times: 5.9 (P = 0.02)]. But, the concordance rate was decreased in high grade dysplasia (coefficient −40.32, P = 0.006).

Patients and methods: One hundred and sixty GENs from 148 patients were randomized into two groups and finally 67 GENs in 61 patients and 65 GENs in 63 patients were allocated to the conventional group (CG) or jumbo group (JG), respectively. Four endoscopic forceps biopsy (EFB) specimens were obtained from each lesion with conventional (6.8 mm) forceps or jumbo (8 mm) forceps. The histological concordance rate between 4 EFB specimens and ESD specimens was investigated in the two groups.

Conclusions: Before ESD, the diagnostic accuracy of GENs was significantly increased not by the use of jumbo forceps biopsy but by increasing the number of biopsies.

Original language	English
Pages (from-to)	661-668
Number of pages	8
Journal	Gastric Cancer
Volume	17
Issue number	4
DOIs	https://doi.org/10.1007/s10120-013-0322-2
Publication status	Published - 2014 Sept 20

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012-0004734).

Publisher Copyright:
© 2013, The International Gastric Cancer Association and The Japanese Gastric Cancer Association.

All Science Journal Classification (ASJC) codes

Oncology
Gastroenterology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10120-013-0322-2

Cite this

Jeon, H. K., Ryu, H. Y., Cho, M. Y., Kim, H. S., Kim, J. W., Park, H. J., Kim, M. Y., Baik, S. K., Kwon, S. O., Park, S. Y., & Won, S. H. (2014). A randomized trial to determine the diagnostic accuracy of conventional vs. jumbo forceps biopsy of gastric epithelial neoplasias before endoscopic submucosal dissection; open-label study. Gastric Cancer, 17(4), 661-668. https://doi.org/10.1007/s10120-013-0322-2

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title = "A randomized trial to determine the diagnostic accuracy of conventional vs. jumbo forceps biopsy of gastric epithelial neoplasias before endoscopic submucosal dissection; open-label study",

abstract = "Background and aims: Larger biopsy specimens or increasing the number of biopsies may improve the diagnostic accuracy of gastric epithelial neoplasia (GEN). The aims of this study was to compare the diagnostic accuracies between conventional and jumbo forceps biopsy of GEN before endoscopic submucosal dissection (ESD) and to confirm that increasing the number of biopsies is useful for the diagnosis of GEN.Results: The concordance rate between EFB and ESD specimens was not significantly different between the two groups [83.1 % (54/65) in JG vs. 79.1 % (53/67) in CG]. On multivariate analyses, two or four EFBs significantly increased the cumulating concordance rate [coefficients; twice: 5.1 (P = 0.01), four times: 5.9 (P = 0.02)]. But, the concordance rate was decreased in high grade dysplasia (coefficient −40.32, P = 0.006).Patients and methods: One hundred and sixty GENs from 148 patients were randomized into two groups and finally 67 GENs in 61 patients and 65 GENs in 63 patients were allocated to the conventional group (CG) or jumbo group (JG), respectively. Four endoscopic forceps biopsy (EFB) specimens were obtained from each lesion with conventional (6.8 mm) forceps or jumbo (8 mm) forceps. The histological concordance rate between 4 EFB specimens and ESD specimens was investigated in the two groups.Conclusions: Before ESD, the diagnostic accuracy of GENs was significantly increased not by the use of jumbo forceps biopsy but by increasing the number of biopsies.",

author = "Jeon, {Hyo Keun} and Ryu, {Ho Yoel} and Cho, {Mee Yon} and Kim, {Hyun Soo} and Kim, {Jae Woo} and Park, {Hong Jun} and Kim, {Moon Young} and Baik, {Soon Koo} and Kwon, {Sang Ok} and Park, {Su Yeon} and Won, {Sung Ho}",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012-0004734). Publisher Copyright: {\textcopyright} 2013, The International Gastric Cancer Association and The Japanese Gastric Cancer Association.",

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Jeon, HK, Ryu, HY, Cho, MY , Kim, HS, Kim, JW, Park, HJ, Kim, MY , Baik, SK, Kwon, SO, Park, SY & Won, SH 2014, 'A randomized trial to determine the diagnostic accuracy of conventional vs. jumbo forceps biopsy of gastric epithelial neoplasias before endoscopic submucosal dissection; open-label study', Gastric Cancer, vol. 17, no. 4, pp. 661-668. https://doi.org/10.1007/s10120-013-0322-2

TY - JOUR

T1 - A randomized trial to determine the diagnostic accuracy of conventional vs. jumbo forceps biopsy of gastric epithelial neoplasias before endoscopic submucosal dissection; open-label study

AU - Jeon, Hyo Keun

AU - Ryu, Ho Yoel

AU - Cho, Mee Yon

AU - Kim, Hyun Soo

AU - Kim, Jae Woo

AU - Park, Hong Jun

AU - Kim, Moon Young

AU - Baik, Soon Koo

AU - Kwon, Sang Ok

AU - Park, Su Yeon

AU - Won, Sung Ho

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012-0004734). Publisher Copyright: © 2013, The International Gastric Cancer Association and The Japanese Gastric Cancer Association.

PY - 2014/9/20

Y1 - 2014/9/20

N2 - Background and aims: Larger biopsy specimens or increasing the number of biopsies may improve the diagnostic accuracy of gastric epithelial neoplasia (GEN). The aims of this study was to compare the diagnostic accuracies between conventional and jumbo forceps biopsy of GEN before endoscopic submucosal dissection (ESD) and to confirm that increasing the number of biopsies is useful for the diagnosis of GEN.Results: The concordance rate between EFB and ESD specimens was not significantly different between the two groups [83.1 % (54/65) in JG vs. 79.1 % (53/67) in CG]. On multivariate analyses, two or four EFBs significantly increased the cumulating concordance rate [coefficients; twice: 5.1 (P = 0.01), four times: 5.9 (P = 0.02)]. But, the concordance rate was decreased in high grade dysplasia (coefficient −40.32, P = 0.006).Patients and methods: One hundred and sixty GENs from 148 patients were randomized into two groups and finally 67 GENs in 61 patients and 65 GENs in 63 patients were allocated to the conventional group (CG) or jumbo group (JG), respectively. Four endoscopic forceps biopsy (EFB) specimens were obtained from each lesion with conventional (6.8 mm) forceps or jumbo (8 mm) forceps. The histological concordance rate between 4 EFB specimens and ESD specimens was investigated in the two groups.Conclusions: Before ESD, the diagnostic accuracy of GENs was significantly increased not by the use of jumbo forceps biopsy but by increasing the number of biopsies.

AB - Background and aims: Larger biopsy specimens or increasing the number of biopsies may improve the diagnostic accuracy of gastric epithelial neoplasia (GEN). The aims of this study was to compare the diagnostic accuracies between conventional and jumbo forceps biopsy of GEN before endoscopic submucosal dissection (ESD) and to confirm that increasing the number of biopsies is useful for the diagnosis of GEN.Results: The concordance rate between EFB and ESD specimens was not significantly different between the two groups [83.1 % (54/65) in JG vs. 79.1 % (53/67) in CG]. On multivariate analyses, two or four EFBs significantly increased the cumulating concordance rate [coefficients; twice: 5.1 (P = 0.01), four times: 5.9 (P = 0.02)]. But, the concordance rate was decreased in high grade dysplasia (coefficient −40.32, P = 0.006).Patients and methods: One hundred and sixty GENs from 148 patients were randomized into two groups and finally 67 GENs in 61 patients and 65 GENs in 63 patients were allocated to the conventional group (CG) or jumbo group (JG), respectively. Four endoscopic forceps biopsy (EFB) specimens were obtained from each lesion with conventional (6.8 mm) forceps or jumbo (8 mm) forceps. The histological concordance rate between 4 EFB specimens and ESD specimens was investigated in the two groups.Conclusions: Before ESD, the diagnostic accuracy of GENs was significantly increased not by the use of jumbo forceps biopsy but by increasing the number of biopsies.

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DO - 10.1007/s10120-013-0322-2

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AN - SCOPUS:84919381261

SN - 1436-3291

VL - 17

SP - 661

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JO - Gastric Cancer

JF - Gastric Cancer

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ER -

A randomized trial to determine the diagnostic accuracy of conventional vs. jumbo forceps biopsy of gastric epithelial neoplasias before endoscopic submucosal dissection; open-label study

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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