A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

Natalia P. Achkar; Seok Keun Cho; Christian Poulsen; Agustin L. Arce; Delfina A. Re; Axel J. Giudicatti; Elizabeth Karayekov; Moon Young Ryu; Suk Won Choi; Jesper Harholt; Jorge J. Casal; Seong Wook Yang; Pablo A. Manavella

doi:10.1016/j.devcel.2018.06.014

A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

Natalia P. Achkar, Seok Keun Cho, Christian Poulsen, Agustin L. Arce, Delfina A. Re, Axel J. Giudicatti, Elizabeth Karayekov, Moon Young Ryu, Suk Won Choi, Jesper Harholt, Jorge J. Casal, Seong Wook Yang, Pablo A. Manavella

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Abstract

Achkar et al. show that a nuclear reserve pool of inactive phosphorylated HYL1, an essential cofactor for microRNA biogenesis, is resistant to dark- or shade-induced degradation. Upon light restoration, this HYL1 pool is quickly dephosphorylated to rapidly restore miRNA production and switch the developmental program to light-dependent growth.

Original language	English
Pages (from-to)	236-247.e6
Journal	Developmental Cell
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2018.06.014
Publication status	Published - 2018 Jul 16

Bibliographical note

Funding Information:
This work was supported by grants from ANPCyT (Agencia Nacional de Promoción Científica y Tecnológica, Argentina), HFSP (Human Frontier Science Program), and the Max Planck Society , ICGEB (International Centre for Genetic Engineering and Biotechnology) to P.A.M.; Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (grant number: NRF-2017R1A2B4010255 ), the VILLUM Research Center “Plant Plasticity” , and the Center for Synthetic Biology “bioSYNergy” (UCPH Excellence Programme for Interdisciplinary Research) to S.W.Y.; NRF-2016R1C1B1013506 to S.K.C.; and NRF-2017R1A6A3A11035981 to M.Y.R. P.A.M., J.J.C., A.L.A., and D.A.R. are members of CONICET; N.P.A. is a fellow of the same institution.

Funding Information:
This work was supported by grants from ANPCyT (Agencia Nacional de Promoci?n Cient?fica y Tecnol?gica, Argentina), HFSP (Human Frontier Science Program), and the Max Planck Society, ICGEB (International Centre for Genetic Engineering and Biotechnology) to P.A.M.; Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (grant number: NRF-2017R1A2B4010255), the VILLUM Research Center ?Plant Plasticity? and the Center for Synthetic Biology ?bioSYNergy? (UCPH Excellence Programme for Interdisciplinary Research) to S.W.Y.; NRF-2016R1C1B1013506 to S.K.C.; and NRF-2017R1A6A3A11035981 to M.Y.R. P.A.M., J.J.C., A.L.A., and D.A.R. are members of CONICET; N.P.A. is a fellow of the same institution.

All Science Journal Classification (ASJC) codes

Molecular Biology
General Biochemistry,Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2018.06.014

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Achkar, N. P., Cho, S. K., Poulsen, C., Arce, A. L., Re, D. A., Giudicatti, A. J., Karayekov, E., Ryu, M. Y., Choi, S. W., Harholt, J., Casal, J. J., Yang, S. W., & Manavella, P. A. (2018). A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation. Developmental Cell, 46(2), 236-247.e6. https://doi.org/10.1016/j.devcel.2018.06.014

@article{51c09bced47b469f81263136de1e6ee4,

title = "A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation",

abstract = "Achkar et al. show that a nuclear reserve pool of inactive phosphorylated HYL1, an essential cofactor for microRNA biogenesis, is resistant to dark- or shade-induced degradation. Upon light restoration, this HYL1 pool is quickly dephosphorylated to rapidly restore miRNA production and switch the developmental program to light-dependent growth.",

keywords = "Arabidopsis, HYL1, gene silencing, light response, microRNAs, phosphorylation, shade",

author = "Achkar, {Natalia P.} and Cho, {Seok Keun} and Christian Poulsen and Arce, {Agustin L.} and Re, {Delfina A.} and Giudicatti, {Axel J.} and Elizabeth Karayekov and Ryu, {Moon Young} and Choi, {Suk Won} and Jesper Harholt and Casal, {Jorge J.} and Yang, {Seong Wook} and Manavella, {Pablo A.}",

note = "Funding Information: This work was supported by grants from ANPCyT (Agencia Nacional de Promoci{\'o}n Cient{\'i}fica y Tecnol{\'o}gica, Argentina), HFSP (Human Frontier Science Program), and the Max Planck Society , ICGEB (International Centre for Genetic Engineering and Biotechnology) to P.A.M.; Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (grant number: NRF-2017R1A2B4010255 ), the VILLUM Research Center “Plant Plasticity” , and the Center for Synthetic Biology “bioSYNergy” (UCPH Excellence Programme for Interdisciplinary Research) to S.W.Y.; NRF-2016R1C1B1013506 to S.K.C.; and NRF-2017R1A6A3A11035981 to M.Y.R. P.A.M., J.J.C., A.L.A., and D.A.R. are members of CONICET; N.P.A. is a fellow of the same institution. Funding Information: This work was supported by grants from ANPCyT (Agencia Nacional de Promoci?n Cient?fica y Tecnol?gica, Argentina), HFSP (Human Frontier Science Program), and the Max Planck Society, ICGEB (International Centre for Genetic Engineering and Biotechnology) to P.A.M.; Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (grant number: NRF-2017R1A2B4010255), the VILLUM Research Center ?Plant Plasticity? and the Center for Synthetic Biology ?bioSYNergy? (UCPH Excellence Programme for Interdisciplinary Research) to S.W.Y.; NRF-2016R1C1B1013506 to S.K.C.; and NRF-2017R1A6A3A11035981 to M.Y.R. P.A.M., J.J.C., A.L.A., and D.A.R. are members of CONICET; N.P.A. is a fellow of the same institution.",

year = "2018",

month = jul,

day = "16",

doi = "10.1016/j.devcel.2018.06.014",

language = "English",

volume = "46",

pages = "236--247.e6",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "2",

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Achkar, NP, Cho, SK, Poulsen, C, Arce, AL, Re, DA, Giudicatti, AJ, Karayekov, E, Ryu, MY, Choi, SW, Harholt, J, Casal, JJ, Yang, SW & Manavella, PA 2018, 'A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation', Developmental Cell, vol. 46, no. 2, pp. 236-247.e6. https://doi.org/10.1016/j.devcel.2018.06.014

TY - JOUR

T1 - A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

AU - Achkar, Natalia P.

AU - Cho, Seok Keun

AU - Poulsen, Christian

AU - Arce, Agustin L.

AU - Re, Delfina A.

AU - Giudicatti, Axel J.

AU - Karayekov, Elizabeth

AU - Ryu, Moon Young

AU - Choi, Suk Won

AU - Harholt, Jesper

AU - Casal, Jorge J.

AU - Yang, Seong Wook

AU - Manavella, Pablo A.

N1 - Funding Information: This work was supported by grants from ANPCyT (Agencia Nacional de Promoción Científica y Tecnológica, Argentina), HFSP (Human Frontier Science Program), and the Max Planck Society , ICGEB (International Centre for Genetic Engineering and Biotechnology) to P.A.M.; Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (grant number: NRF-2017R1A2B4010255 ), the VILLUM Research Center “Plant Plasticity” , and the Center for Synthetic Biology “bioSYNergy” (UCPH Excellence Programme for Interdisciplinary Research) to S.W.Y.; NRF-2016R1C1B1013506 to S.K.C.; and NRF-2017R1A6A3A11035981 to M.Y.R. P.A.M., J.J.C., A.L.A., and D.A.R. are members of CONICET; N.P.A. is a fellow of the same institution. Funding Information: This work was supported by grants from ANPCyT (Agencia Nacional de Promoci?n Cient?fica y Tecnol?gica, Argentina), HFSP (Human Frontier Science Program), and the Max Planck Society, ICGEB (International Centre for Genetic Engineering and Biotechnology) to P.A.M.; Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (grant number: NRF-2017R1A2B4010255), the VILLUM Research Center ?Plant Plasticity? and the Center for Synthetic Biology ?bioSYNergy? (UCPH Excellence Programme for Interdisciplinary Research) to S.W.Y.; NRF-2016R1C1B1013506 to S.K.C.; and NRF-2017R1A6A3A11035981 to M.Y.R. P.A.M., J.J.C., A.L.A., and D.A.R. are members of CONICET; N.P.A. is a fellow of the same institution.

PY - 2018/7/16

Y1 - 2018/7/16

N2 - Achkar et al. show that a nuclear reserve pool of inactive phosphorylated HYL1, an essential cofactor for microRNA biogenesis, is resistant to dark- or shade-induced degradation. Upon light restoration, this HYL1 pool is quickly dephosphorylated to rapidly restore miRNA production and switch the developmental program to light-dependent growth.

AB - Achkar et al. show that a nuclear reserve pool of inactive phosphorylated HYL1, an essential cofactor for microRNA biogenesis, is resistant to dark- or shade-induced degradation. Upon light restoration, this HYL1 pool is quickly dephosphorylated to rapidly restore miRNA production and switch the developmental program to light-dependent growth.

KW - Arabidopsis

KW - HYL1

KW - gene silencing

KW - light response

KW - microRNAs

KW - phosphorylation

KW - shade

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DO - 10.1016/j.devcel.2018.06.014

M3 - Article

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AN - SCOPUS:85049303033

SN - 1534-5807

VL - 46

SP - 236-247.e6

JO - Developmental Cell

JF - Developmental Cell

IS - 2

ER -

A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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