A prognostic model to predict clinical outcome in gastric cancer patients with bone metastasis

Hyung Soon Park, Sun Young Rha, Hyo Song Kim, Woo Jin Hyung, Ji Soo Park, Hyun Cheol Chung, Sung Hoon Noh, Hei Cheul Jeung

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)


Background: The clinicopathological manifestations and treatment outcomes of bone metastasis of gastric cancer are largely unknown. We delineated a prognostic model to identify different risk groups on the basis of clinical parameters. Methods: Patients who had bone metastasis at the time of diagnosis of gastric cancer (synchronous metastasis) or who developed bone metastasis during follow-up (metachronous metastasis) were retrospectively reviewed from January 1998 to May 2008. Results: Bone metastasis was identified in 203 (2.4%) of 8,633 patients: 126 patients (62%) with synchronous metastasis and 77 patients with metachronous metastasis. The median time to event was 16 months (range 4-87). As for treatment, 120 patients (59%) received systemic chemotherapy. The median survival time was 103 days (95% CI 80-126). Poor performance status [Eastern Cooperative Oncology Group 3-4; relative risk (RR) = 1.91, p = 0.011], multiple bone metastasis (RR = 2.593, p = 0.002), and abnormal carcinoembryonic antigen (RR = 1.779, p = 0.004) implied independent factors for survival. For patients who had zero to two of these factors identified, chemotherapy had a beneficial effect (175 vs. 43 days; p < 0.0001). Conclusion: We recommend that the therapeutic approach with bone metastasis be customized to facilitate the risk stratification, so as to consequently provide the most appropriate therapy for each patient.

Original languageEnglish
Pages (from-to)142-150
Number of pages9
Issue number1-2
Publication statusPublished - 2011 Jun

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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