Cl3CCN in combination with PPh3 proved to be a highly reactive reagent for the conversion of sulfonic acids to the corresponding sulfonyl chlorides in refluxing CH2Cl2. Upon reaction with amines, the corresponding sulfonamides were obtained in good to excellent yields.
Bibliographical noteFunding Information:
This work was supported by a joint research project under the NRCT-KOSEF international cooperative program (KO 47/2547). O.C. and W.C. are also indebted to the Graduate school, Chulalongkorn University, for financial support.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry