A one-pot total synthesis of crambin

Duhee Bang; Stephen B.H. Kent

doi:10.1002/anie.200353540

A one-pot total synthesis of crambin

Duhee Bang, Stephen B.H. Kent

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

272 Citations (Scopus)

Abstract

Making up for lost time: The one-pot synthesis of crambin (see structure) with only a single final purification step gave the target protein of exceptional purity in only two days with an overall yield of ≈40%. Three unprotected peptide segments were linked by native chemical ligation, and the polypeptide chain assumed its 3D structure without intermediate purification steps.

Original language	English
Pages (from-to)	2534-2538
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	19
DOIs	https://doi.org/10.1002/anie.200353540
Publication status	Published - 2004 May 3

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

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10.1002/anie.200353540

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A one-pot total synthesis of crambin

Abstract

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