A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization

Ikyon Kim; Hye Kyoung Won; Jihyun Choi; Ge Hyeong Lee

doi:10.1016/j.tet.2007.10.037

A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization

Ikyon Kim, Hye Kyoung Won, Jihyun Choi, Ge Hyeong Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt. This mild procedure enabled us to synthesize a number of highly substituted indolizines in good yields.

Original language	English
Pages (from-to)	12954-12960
Number of pages	7
Journal	Tetrahedron
Volume	63
Issue number	52
DOIs	https://doi.org/10.1016/j.tet.2007.10.037
Publication status	Published - 2007 Dec 24

Bibliographical note

Funding Information:
We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for generous financial support.

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2007.10.037

Cite this

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abstract = "A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt. This mild procedure enabled us to synthesize a number of highly substituted indolizines in good yields.",

author = "Ikyon Kim and Won, {Hye Kyoung} and Jihyun Choi and Lee, {Ge Hyeong}",

note = "Funding Information: We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for generous financial support. ",

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AU - Won, Hye Kyoung

AU - Choi, Jihyun

AU - Lee, Ge Hyeong

N1 - Funding Information: We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for generous financial support.

PY - 2007/12/24

Y1 - 2007/12/24

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AB - A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt. This mild procedure enabled us to synthesize a number of highly substituted indolizines in good yields.

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A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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