A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells

Kyung Noo Kim; Jiyong Lee; Dong Hoon Kim; Jong Shin Yoo; Ho Jeong Kwon

doi:10.1016/j.bmcl.2004.10.039

A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells

Kyung Noo Kim, Jiyong Lee, Dong Hoon Kim, Jong Shin Yoo, Ho Jeong Kwon

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The synthesis of new thymidine analogues and their biological activities are described. Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC ₅₀ of 15 μM.

Original language	English
Pages (from-to)	77-79
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2004.10.039
Publication status	Published - 2005 Jan 3

Bibliographical note

Funding Information:
This study was supported by the National Research Laboratory Grant from the Ministry of Science and Technology, Republic of Korea and the Brain Korea 21 Project.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.10.039

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abstract = "The synthesis of new thymidine analogues and their biological activities are described. Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC 50 of 15 μM.",

author = "Kim, {Kyung Noo} and Jiyong Lee and Kim, {Dong Hoon} and Yoo, {Jong Shin} and Kwon, {Ho Jeong}",

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AU - Lee, Jiyong

AU - Kim, Dong Hoon

AU - Yoo, Jong Shin

AU - Kwon, Ho Jeong

N1 - Funding Information: This study was supported by the National Research Laboratory Grant from the Ministry of Science and Technology, Republic of Korea and the Brain Korea 21 Project.

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Y1 - 2005/1/3

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A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells

Abstract

Bibliographical note

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UN SDGs

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