A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus

Tran Minh Ngoc, Nguyen Thi Thanh Phuong, Nguyen Minh Khoi, Seon Ju Park, Hee Jae Kwak, Nguyen Xuan Nhiem, Bui Thi Thu Trang, Bui Huu Tai, Jae Hyoung Song, Hyun Jeong Ko, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of fungal and herpes virus infections. A new naphthoquinone racemate, rhinacasutone (1) together with seven known compounds, rhinacanthone (2), rhinacanthins C, D, N, Q, and E (3–7), and heliobuphthalmin (8) were isolated from root of R. nasutus. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR and MS data. All the isolated compounds were tested for their antiviral activities against PR8, HRV1B, and CVB3-infected vero cells. Compounds 3–6 exhibited significant antiviral activities with the IC50 value ranging from 0.03 to 23.7 μM in all three infections.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalNatural Product Research
Issue number3
Publication statusPublished - 2019 Feb 1

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) [grant number NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.

Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry


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