A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus

Tran Minh Ngoc; Nguyen Thi Thanh Phuong; Nguyen Minh Khoi; Seon Ju Park; Hee Jae Kwak; Nguyen Xuan Nhiem; Bui Thi Thu Trang; Bui Huu Tai; Jae Hyoung Song; Hyun Jeong Ko; Seung Hyun Kim

doi:10.1080/14786419.2018.1452004

A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus

Tran Minh Ngoc, Nguyen Thi Thanh Phuong, Nguyen Minh Khoi, Seon Ju Park, Hee Jae Kwak, Nguyen Xuan Nhiem, Bui Thi Thu Trang, Bui Huu Tai, Jae Hyoung Song, Hyun Jeong Ko, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of fungal and herpes virus infections. A new naphthoquinone racemate, rhinacasutone (1) together with seven known compounds, rhinacanthone (2), rhinacanthins C, D, N, Q, and E (3–7), and heliobuphthalmin (8) were isolated from root of R. nasutus. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR and MS data. All the isolated compounds were tested for their antiviral activities against PR8, HRV1B, and CVB3-infected vero cells. Compounds 3–6 exhibited significant antiviral activities with the IC₅₀ value ranging from 0.03 to 23.7 μM in all three infections.

Original language	English
Pages (from-to)	360-366
Number of pages	7
Journal	Natural Product Research
Volume	33
Issue number	3
DOIs	https://doi.org/10.1080/14786419.2018.1452004
Publication status	Published - 2019 Feb 1

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) [grant number NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.

Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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title = "A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus",

abstract = "Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of fungal and herpes virus infections. A new naphthoquinone racemate, rhinacasutone (1) together with seven known compounds, rhinacanthone (2), rhinacanthins C, D, N, Q, and E (3–7), and heliobuphthalmin (8) were isolated from root of R. nasutus. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR and MS data. All the isolated compounds were tested for their antiviral activities against PR8, HRV1B, and CVB3-infected vero cells. Compounds 3–6 exhibited significant antiviral activities with the IC50 value ranging from 0.03 to 23.7 μM in all three infections.",

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AU - Nhiem, Nguyen Xuan

AU - Trang, Bui Thi Thu

AU - Tai, Bui Huu

AU - Song, Jae Hyoung

AU - Ko, Hyun Jeong

AU - Kim, Seung Hyun

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A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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