A mixed micellar formulation for the transdermal delivery of an Indirubin analog

Seol Hwa Seo; Eunhwan Kim; Yechan Joo; Juseung Lee; Kyung Taek Oh; Sung Joo Hwang; Kang Yell Choi

doi:10.3390/pharmaceutics12020175

A mixed micellar formulation for the transdermal delivery of an Indirubin analog

Seol Hwa Seo, Eunhwan Kim, Yechan Joo, Juseung Lee, Kyung Taek Oh, Sung Joo Hwang, Kang Yell Choi

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Indirubin is an active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases as well as for the prevention and treatment of human cancer, such as chronic myeloid leukemia. The therapeutic effects of indirubin analogs have been underestimated due to its poor water solubility and low bioavailability. To improve the solubility and bioavailability of indirubin analogs, we prepared a mixed micellar formulation with Kolliphor® EL and Tween 80 as surfactants, and PEG 400 as a co-surfactant, followed by complexation with (2-hydroxyproply)-β-cyclodextrin at appropriate ratios. Overall, improving the solubility and skin penetration of indirubin analogs can increase clinical efficacy and provide maximum flux through the skin.

Original language	English
Article number	175
Journal	Pharmaceutics
Volume	12
Issue number	2
DOIs	https://doi.org/10.3390/pharmaceutics12020175
Publication status	Published - 2020 Feb

Bibliographical note

Funding Information:
This work was supported by a grant from the National Research Foundation (NRF), the Ministry of Information and Science and ICT of Korea; A Mid-Career Researcher Program National Research Lab (2019R1A2C3002751).

Funding Information:
Funding: This work was supported by a grant from the National Research Foundation (NRF), the Ministry of Information and Science and ICT of Korea; A Mid-Career Researcher Program National Research Lab (2019R1A2C3002751).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pharmaceutics12020175

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abstract = "Indirubin is an active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases as well as for the prevention and treatment of human cancer, such as chronic myeloid leukemia. The therapeutic effects of indirubin analogs have been underestimated due to its poor water solubility and low bioavailability. To improve the solubility and bioavailability of indirubin analogs, we prepared a mixed micellar formulation with Kolliphor{\textregistered} EL and Tween 80 as surfactants, and PEG 400 as a co-surfactant, followed by complexation with (2-hydroxyproply)-β-cyclodextrin at appropriate ratios. Overall, improving the solubility and skin penetration of indirubin analogs can increase clinical efficacy and provide maximum flux through the skin.",

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AU - Seo, Seol Hwa

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AU - Joo, Yechan

AU - Lee, Juseung

AU - Oh, Kyung Taek

AU - Hwang, Sung Joo

AU - Choi, Kang Yell

N1 - Funding Information: This work was supported by a grant from the National Research Foundation (NRF), the Ministry of Information and Science and ICT of Korea; A Mid-Career Researcher Program National Research Lab (2019R1A2C3002751). Funding Information: Funding: This work was supported by a grant from the National Research Foundation (NRF), the Ministry of Information and Science and ICT of Korea; A Mid-Career Researcher Program National Research Lab (2019R1A2C3002751). Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2020/2

Y1 - 2020/2

N2 - Indirubin is an active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases as well as for the prevention and treatment of human cancer, such as chronic myeloid leukemia. The therapeutic effects of indirubin analogs have been underestimated due to its poor water solubility and low bioavailability. To improve the solubility and bioavailability of indirubin analogs, we prepared a mixed micellar formulation with Kolliphor® EL and Tween 80 as surfactants, and PEG 400 as a co-surfactant, followed by complexation with (2-hydroxyproply)-β-cyclodextrin at appropriate ratios. Overall, improving the solubility and skin penetration of indirubin analogs can increase clinical efficacy and provide maximum flux through the skin.

AB - Indirubin is an active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases as well as for the prevention and treatment of human cancer, such as chronic myeloid leukemia. The therapeutic effects of indirubin analogs have been underestimated due to its poor water solubility and low bioavailability. To improve the solubility and bioavailability of indirubin analogs, we prepared a mixed micellar formulation with Kolliphor® EL and Tween 80 as surfactants, and PEG 400 as a co-surfactant, followed by complexation with (2-hydroxyproply)-β-cyclodextrin at appropriate ratios. Overall, improving the solubility and skin penetration of indirubin analogs can increase clinical efficacy and provide maximum flux through the skin.

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A mixed micellar formulation for the transdermal delivery of an Indirubin analog

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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