A miniature headstage for high resolution closed-loop optogenetics

Adam E. Mendrela; Kanghwan Kim; Daniel English; Sam McKenzie; John Seymour; György Buzsáki; Euisik Yoon

doi:10.1109/BIOCAS.2017.8325187

A miniature headstage for high resolution closed-loop optogenetics

Adam E. Mendrela, Kanghwan Kim, Daniel English, Sam McKenzie, John Seymour, György Buzsáki, Euisik Yoon

Yonsei Advanced Science Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Citations (Scopus)

Abstract

We present a novel integrated miniature headstage for high-density closed-loop optogenetics studies with the highest published channel count to date. The headstage performs optical stimulation and electrical neural recording through a monolithically integrated electrode with 12 or 32 μLEDs and 32 recording sites. The electronic back-end consists of a custom 48-channel LED driver IC capable of real-time individual channel control at 10-bit optical power precision and a 32-channel off-the-shelf neural recording IC. The system's functionality was proven in vivo through high-precision neuronal stimulation in a mouse hippocampus.

Original language	English
Title of host publication	2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1-4
Number of pages	4
ISBN (Electronic)	9781509058037
DOIs	https://doi.org/10.1109/BIOCAS.2017.8325187
Publication status	Published - 2018 Mar 23
Event	2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Torino, Italy Duration: 2017 Oct 19 → 2017 Oct 21

Publication series

Name	2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
Volume	2018-January

Other

Other	2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017
Country/Territory	Italy
City	Torino
Period	17/10/19 → 17/10/21

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS This work has been supported in part by NIH R21-EB019221 and in part by NSF 1545858. We would also like to thank Sagnik Dam for help with headstage PCB design.

Publisher Copyright:
© 2017 IEEE.

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Electrical and Electronic Engineering
Instrumentation

Access to Document

10.1109/BIOCAS.2017.8325187

Cite this

Mendrela, A. E., Kim, K., English, D., McKenzie, S., Seymour, J., Buzsáki, G., & Yoon, E. (2018). A miniature headstage for high resolution closed-loop optogenetics. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings (pp. 1-4). (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings; Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIOCAS.2017.8325187

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abstract = "We present a novel integrated miniature headstage for high-density closed-loop optogenetics studies with the highest published channel count to date. The headstage performs optical stimulation and electrical neural recording through a monolithically integrated electrode with 12 or 32 μLEDs and 32 recording sites. The electronic back-end consists of a custom 48-channel LED driver IC capable of real-time individual channel control at 10-bit optical power precision and a 32-channel off-the-shelf neural recording IC. The system's functionality was proven in vivo through high-precision neuronal stimulation in a mouse hippocampus.",

author = "Mendrela, {Adam E.} and Kanghwan Kim and Daniel English and Sam McKenzie and John Seymour and Gy{\"o}rgy Buzs{\'a}ki and Euisik Yoon",

note = "Funding Information: ACKNOWLEDGMENTS This work has been supported in part by NIH R21-EB019221 and in part by NSF 1545858. We would also like to thank Sagnik Dam for help with headstage PCB design. Publisher Copyright: {\textcopyright} 2017 IEEE.; 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 ; Conference date: 19-10-2017 Through 21-10-2017",

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Mendrela, AE, Kim, K, English, D, McKenzie, S, Seymour, J, Buzsáki, G & Yoon, E 2018, A miniature headstage for high resolution closed-loop optogenetics. in 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings, vol. 2018-January, Institute of Electrical and Electronics Engineers Inc., pp. 1-4, 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017, Torino, Italy, 17/10/19. https://doi.org/10.1109/BIOCAS.2017.8325187

A miniature headstage for high resolution closed-loop optogenetics. / Mendrela, Adam E.; Kim, Kanghwan; English, Daniel et al.
2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. p. 1-4 (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings; Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - English, Daniel

AU - McKenzie, Sam

AU - Seymour, John

AU - Buzsáki, György

AU - Yoon, Euisik

N1 - Funding Information: ACKNOWLEDGMENTS This work has been supported in part by NIH R21-EB019221 and in part by NSF 1545858. We would also like to thank Sagnik Dam for help with headstage PCB design. Publisher Copyright: © 2017 IEEE.

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Mendrela AE, Kim K, English D, McKenzie S, Seymour J, Buzsáki G et al. A miniature headstage for high resolution closed-loop optogenetics. In 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2018. p. 1-4. (2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings). doi: 10.1109/BIOCAS.2017.8325187

A miniature headstage for high resolution closed-loop optogenetics

Abstract

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